背景:大黄素是一种天然的生物活性成分,主要从传统中草药中提取。越来越多的证据表明大黄素及其类似物与其他生物活性化合物具有显著的协同药理作用。
目的:这篇综述概述了大黄素及其类似物与其他生理活性物质组合的药理活性,描述了相关的分子机制,并讨论了该领域的未来前景。
方法:来自多个科学数据库的信息,比如PubMed,来自中国国家知识基础设施的中国知识资源综合数据库(CNKI),WebofScience,谷歌学者,和百度学者,收集时间为2006年1月至2022年8月。文献检索中使用的主题词是大黄素,药学活动,类似物,芦荟大黄素,rhein,和协同效应。
结果:综合文献分析表明,大黄素或其类似物与其他生物活性化合物的组合具有显著的协同抗癌作用,抗炎,和抗微生物作用,并且这种组合可以改善葡萄糖和脂质代谢以及中枢神经系统疾病。
结论:需要进一步评估大黄素或其类似物与其他生物活性化合物在各种给药方式中的剂量-效应关系和功效差异,并且需要仔细进行这些组合的药物安全性评估。未来的研究还应该集中在确定特定疾病的最佳药物组合上。
BACKGROUND: Emodin is a natural bioactive ingredient mainly extracted from traditional Chinese herbs. Increasing lines of evidence suggest that emodin and its analogs exert notable synergistic pharmacological effects with other bioactive compounds.
OBJECTIVE: This review provides an overview of the pharmacological activity of emodin and its analogs in combination with other physiologically active substances, describes the related molecular mechanisms, and discusses future prospects in this field.
METHODS: Information from multiple scientific databases, such as PubMed, the China Knowledge Resource Integrated Database from the China National Knowledge Infrastructure (CNKI), the Web of Science, Google Scholar, and Baidu Scholar, was collected between January 2006 and August 2022. The subject terms used in the literature search were emodin, pharmaceutical activities, analogs, aloe emodin, rhein, and synergistic effects.
RESULTS: The comprehensive literature analysis suggested that combinations of emodin or its analogs with other bioactive compounds exert notable synergistic anticancer, anti-inflammatory, and antimicrobial effects and that such combinations improve glucose and lipid metabolism and central nervous system diseases.
CONCLUSIONS: Further assessments of the dose-effect relationship and the differences in the efficacy of emodin or its analogs with other bioactive compounds among various modes of administration are needed, and a drug safety evaluation of these combinations needs to be carefully performed. Future studies should also focus on determining the optimal drug combinations for specific diseases.