PDF(Pubmed)
Abstract：
Background: Previous infection with Adenovirus-36 (HAdv-D36) has been associated with adipogenesis and glycemic regulation in cell culture and animal models. In humans, HAdv-D36 antibodies correlate with increased obesity risk yet paradoxically enhance glycemic control across various demographics. This study assesses the association of HAdv-D36 seropositivity with obesity, lipid, and glycemic profiles among school-aged children. Methods: We evaluated 208 children aged 9-13, categorized by BMI z-scores into normal weight (-1 to +1), overweight (+1 to +2), and obese (>+3). Assessments included anthropometry, Tanner stage for pubertal development, and biochemical tests (relating to lipids, glucose, and insulin), alongside HAdv-D36 seropositivity checked via ELISA. Insulin resistance was gauged using Chilean pediatric criteria. Results: The cohort displayed a high prevalence of overweight/obesity. HAdv-D36 seropositivity was 5.4%, showing no correlation with nutritional status. Additionally, no link between HAdv-D36 seropositivity and lipid levels was observed. Notably, insulin levels and HOMA-RI were significantly lower in HAdv-D36 positive children (p < 0.001). No cases of insulin resistance were reported in the HAdv-D36 (+) group in our population. Conclusions: HAdv-D36 seropositivity appears to decrease insulin secretion and resistance, aligning with earlier findings. However, no association with obesity development was found in the child population of southern Chile.
摘要：
背景：在细胞培养和动物模型中，腺病毒36（HAdv-D36）的先前感染与脂肪生成和血糖调节有关。在人类中,HAdv-D36抗体与肥胖风险增加相关，但在各种人口统计学中矛盾地增强了血糖控制。这项研究评估了HAdv-D36血清阳性与肥胖的关系，脂质，和学龄儿童的血糖状况。方法：我们评估了208名9-13岁的儿童，根据BMIz评分分为正常体重（-1至1），超重（+1至+2），和肥胖（>+3）。评估包括人体测量,青春期发育的坦纳阶段，和生化测试(与脂质有关，葡萄糖，和胰岛素），通过ELISA检查HAdv-D36血清阳性。使用智利儿科标准测量胰岛素抵抗。结果：该队列显示超重/肥胖的患病率很高。HAdv-D36血清阳性为5.4%，与营养状况无关。此外,未观察到HAdv-D36血清阳性与血脂水平之间的联系.值得注意的是,HAdv-D36阳性儿童的胰岛素水平和HOMA-RI显著降低(p<0.001).在我们的人群中，HAdv-D36（）组未报告胰岛素抵抗的病例。结论：HAdv-D36血清阳性似乎降低胰岛素分泌和抵抗，与先前的发现保持一致。然而,在智利南部的儿童人群中未发现与肥胖发展相关.
