Accidents

事故
  • 文章类型: Journal Article
    这项研究考察了地震灾害对美国西海岸铁路基础设施的影响(华盛顿,俄勒冈州和加利福尼亚州),利用机器学习探索断层密度等地震危险性的衡量标准,地震频率,地面震动与铁路基础设施事故有关。通过比较线性和非线性模型,它发现非线性方法优越,特别指出,较高的断层密度和较强的峰值地面震动与基础设施事故率的增加有关。震级在3.5级以上且震中深度<20km的浅地震也与铁路基础设施事故的发生率显着相关。该研究通过净现值和蒙特卡洛模拟扩展到财务影响分析,并评估2000-2023年的损害成本,以指导财务规划和风险管理战略。它强调了先进的金融工具在优化维护和长期规划方面的关键作用,这些工具可能会在高地震危险区带来更好的准备,并强调需要采取稳健的风险管理策略来提高铁路运营安全性,同时考虑到当地和区域构造和地震活动以及当地的地面震动强度。
    This research examines the seismic hazard impact on railway infrastructure along the U.S. West Coast (Washington, Oregon and California), using machine learning to explore how measures of seismic hazard such as fault density, earthquake frequency, and ground shaking relate to railway infrastructure accidents. By comparing linear and non-linear models, it finds non-linear approaches superior, particularly noting that higher fault densities and stronger peak ground shaking correlate with increased infrastructure accident rates. Shallow earthquakes with magnitudes of 3.5 or greater and hypocentral depths <20 km also exhibit a pronounced correlation with the incidence of railway infrastructure accidents The study extends to financial impact analysis through Net Present Value and Monte Carlo Simulation, and evaluates damage costs from 2000-2023 to guide financial planning and risk management strategies. It highlights the crucial role of advanced financial tools in optimizing maintenance and long-term planning that could result in better preparedness in high seismic hazard regions and emphasizes the need for robust risk management strategies in enhancing railway operational safety that considers the local and regional tectonic and seismic activity and local ground shaking intensity.
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  • 文章类型: Journal Article
    建筑物碰撞是对野生鸟类的主要威胁;然而,只有那些被发现死亡或致命受伤的人才被包括在当前的死亡率估计中,受伤或惊呆的鸟类在很大程度上被认为可以长期生存。禽类建筑碰撞受害者经常被带到野生动物修复人员那里照顾,希望他们能被释放并恢复自然生活。我们检查了在多个季节收集的152种不同鸟类的3,100多次建筑物碰撞的野生动物康复记录,以确定患者的生存和释放模式。入院人数因季节而异;秋季迁徙病例最多,冬季迁徙病例最少,夏季的释放比例最低,冬季的释放比例最高。最常见的报告损伤是头部外伤和脑震荡。我们的逻辑和泊松模型发现质量对释放概率有很强的积极影响,夏季季节对释放概率有很强的负面影响。质量和冬季对治疗时间有很强的积极影响,在这些模型中,年龄和秋季和冬季对治疗时间有很大的负面影响。最终,大约60%的病人在护理中死亡,要么屈服于他们的伤害,要么安乐死。被释放的患者比死亡的患者继续护理的时间更长。这项研究报告了与car体研究不同的数据,并从幸存的受害者的角度看待鸟类建造碰撞,以探索这些碰撞对死亡率的长期影响。建议野生动物修复人员和保护研究人员之间加强沟通和合作,以更好地了解建筑物碰撞以及如何应对这种对野生鸟类的主要威胁。这些发现,加上我们对延迟死亡率的估计,这表明,基于car体收集的整体碰撞死亡率估计在美国每年远远超过10亿只鸟类。
    Building collisions are a leading threat to wild birds; however, only those that are found dead or fatally wounded are included in current mortality estimates, with injured or stunned birds largely assumed to survive long-term. Avian building collision victims are often brought to wildlife rehabilitators for care, with the hopes they can be released and resume their natural lives. We examined the wildlife rehabilitation records of over 3,100 building collisions with 152 different avian species collected across multiple seasons to identify patterns of survival and release among patients. The number of admissions varied by season; fall migration had the highest number of cases and winter had the least number of cases, and summer having the lowest release proportion and winter having the highest. The most common reported injury was head trauma and concussion. Our logistic and Poisson models found that mass had a strong positive effect on release probability, and the season of summer had a strong negative effect on release probability. Mass and winter had a strong positive effect on treatment time, and age and the seasons of fall and winter had a strong negative effect on treatment time in these models. Ultimately, about 60% of patients died in care, either by succumbing to their injuries or by euthanasia. Patients that were released remained in care for longer than patients that died. This study reports different data than carcass studies and views bird-building collisions from the perspective of surviving victims to explore longer-term effects of these collisions on mortality. Increased communication and collaboration between wildlife rehabilitators and conservation researchers is recommended to better understand building collisions and how to respond to this leading threat to wild birds. These findings, along with our estimate of delayed mortality, suggest that overall collision mortality estimates based on carcass collection far exceed one billion birds in the U.S. each year.
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  • 文章类型: Journal Article
    目的:创伤并发症已成为全球最严重的公共卫生问题之一。在大多数报告中,泌尿生殖道损伤(UGI)见于约10%的成人创伤患者和少于3%的腹部或骨盆多发/严重创伤儿童。交通事故是UGI最常见的原因。这项研究的目的是系统地确定车祸后UGI的患病率和类型。
    方法:搜索策略旨在于2023年10月寻找相关研究。没有语言或日期限制。以下标准被认为是资格标准:报告道路交通伤害(RTI)人群中UGI的至少一个流行病学方面,并对UGI中的RTI进行单独的流行病学分析(我们还包括那些指出所有RTI但单独提及UGI的文章)。两名专家使用JoannaBriggs研究所的标准化关键评估工具评估了文章的报告质量。使用CMA统计软件3.2.0版进行本研究的统计分析。
    结果:共有1,466,024例RTIs通过107项研究纳入我们的综述。其中,29项研究与儿童有关(20,036),其他人报告了成人的RTI(1,445,988)。总患病率为4.7%,在36项研究中,车祸是原因,其次是25起摩托车事故,17起自行车事故,以及23项相关研究中的汽车-行人碰撞。在基于受损器官的亚组分析中,膀胱损伤率为3.5%。肾脏的这一比率为5.3%。
    结论:这项系统综述和荟萃分析发现,RTIs后UGI的患病率为4.7%,车祸是最常见的原因。UGI在成人中比在儿童中更普遍,膀胱和肾脏损伤是最常见的报告类型。UGI的患病率因国家和研究设计而异。
    OBJECTIVE: Trauma complications have been one of the most serious public health concerns worldwide. In most reports, urogenital injuries (UGIs) are seen in approximately 10% of adult traumatic patients and less than 3% of children with multiple/severe trauma to the abdomen or pelvis. Traffic accidents are the most common cause of UGIs. The purpose of this study is to systematically determine the prevalence and types of UGIs after car accidents.
    METHODS: The search strategy was aimed at finding relevant studies in October 2023. No restrictions on language or date were applied. The following criteria were considered eligibility criteria: reporting at least one epidemiological aspect of UGIs in people with road traffic injury (RTI) and a separate epidemiological analysis of RTIs in UGI (we also included those articles that pointed out all RTIs but separately mentioned UGIs). Two experts assessed the reporting quality of articles using standardized critical appraisal instruments from the Joanna Briggs Institute. Statistical analysis for this study was conducted using the CMA statistical software version 3.2.0.
    RESULTS: A total of 1,466,024 cases following RTIs through 107 studies were included in our review. Of these, 29 studies were related to children (20,036), and the others reported RTIs in adults (1,445,988). The total prevalence was 4.7%, and car accidents were responsible in 36 studies, followed by motorcycle accidents in 25, bicycles in 17 studies, and automobile-pedestrian collisions in 23 related studies. In subgroup analysis based on the damaged organ, the rate of bladder injury was 3.5%. This rate was 5.3% for kidneys.
    CONCLUSIONS: This systematic review and meta-analysis found that the prevalence of UGI following RTIs was 4.7%, with car accidents being the most common cause. UGIs were more prevalent in adults than in children, and bladder and kidney injuries were the most commonly reported types. The prevalence of UGI varied by country and study design.
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  • 文章类型: Journal Article
    目标:道路交通伤害(RTIs)构成了重大的公共卫生负担,其中一半以上的死亡归因于弱势道路使用者(VRU)。本研究旨在通过关注不同类型的道路使用者来评估韩国严重RTI的流行病学和结果。
    方法:这是一项全国性的回顾性观察研究。使用韩国全国严重创伤登记处的数据,本研究分析了2016年至2020年的严重RTI病例.这项研究包括EMS治疗的严重创伤患者,将严重RTI定义为损伤严重程度评分(ISS)≥16或院外心脏骤停(OHCA)的病例。感兴趣的主要变量是道路用户类型,分类为机动车乘员(MVOs),行人,摩托车手,和骑自行车的人。分析了道路使用者类型的趋势和伤害特征,我们进行了多因素逻辑回归,以计算住院死亡率的道路使用者类型的校正比值比(AORs)和95%置信区间(CIs).
    结果:在143,021例EMS治疗的严重创伤病例中,本研究包括24,464。行人占最大的群体(n=8,782;35.9%)。超过一半的患者死亡(n=12,620,51.6%),高比例的患者患有OHCA(n=10,048,41.1%)。从2016年到2020年,严重RTI的总体数量没有显着变化,但行人病例减少,摩托车手病例增加(趋势均<0.05)。观察到安全装置的使用率较低(28.2%的机动车乘员使用安全带,35.9%的电单车司机使用头盔,和9.6%的骑自行车的人使用头盔)。头部受伤最常见,特别是骑自行车的人(77.0%)和骑摩托车的人(69.8%)。与机动车乘员相比,行人(AOR[95%CI]1.12[1.04-1.20])和其他人(AOR[95%CI]1.30[1.02-1.65])的死亡率较高,而摩托车手(AOR[95%CI]0.64[0.59-0.69])和自行车手(AOR[95%CI]0.68[0.60-0.76])的死亡率较低.
    结论:根据道路使用者类型,我们发现严重RTI的趋势和损伤特征各不相同。针对不断变化的道路使用者模式调整预防策略,特别注意增加安全装置的使用和解决与严重RTI相关的高死亡率是必要的。
    OBJECTIVE: Road traffic injuries (RTIs) pose a significant public health burden, and more than half of these fatalities are attributed to vulnerable road users (VRUs). This study aimed to evaluate the epidemiology and outcomes of severe RTIs in Korea by focusing on different types of road users.
    METHODS: This is nationwide retrospective observational study. Using data from the Korean Nationwide Severe Trauma Registry, this study analyzed severe RTI cases from 2016 to 2020. The study included EMS-treated severe trauma patients, defining severe RTI as cases with an injury severity score (ISS) ≥16 or out-of-hospital cardiac arrest (OHCA). The main variable of interest was the road user type, classified as motor vehicle occupants (MVOs), pedestrians, motorcyclists, and bicyclists. Trends and injury characteristics by road user type were analyzed, and multivariate logistic regression was conducted to calculate the adjusted odds ratios (AORs) and 95 % confidence intervals (CIs) of road user type for in-hospital mortality.
    RESULTS: Of the 143,021 EMS-treated severe trauma cases, 24,464 were included in this study. Pedestrians represented the largest group (n = 8,782; 35.9 %). More than half of the patients died (n = 12,620, 51.6 %), and a high proportion of patients had OHCA (n = 10,048, 41.1 %). There was no significant change in the overall severe RTI numbers from 2016 to 2020, but a decrease in pedestrian cases and an increase in motorcyclist cases were noted (both p for trend<0.05). Low usage of safety devices was observed (28.2 % of motor vehicle occupants used seat belts, 35.9 % of motorcyclists used helmets, and 9.6 % of bicyclists used helmets). Head injuries were most common, particularly among bicyclists (77.0 %) and motorcyclists (69.8 %). Compared to motor vehicle occupants, pedestrians (AOR [95 % CI] 1.12 [1.04-1.20]) and others (AOR [95 % CI] 1.30 [1.02-1.65]) had higher odds of mortality, while motorcyclists (AOR [95 % CI] 0.64 [0.59-0.69]) and bicyclists (AOR [95 % CI] 0.68 [0.60-0.76]) had lower odds of mortality.
    CONCLUSIONS: We found varying trends and injury characteristics in severe RTIs according to road user type. Adapting prevention strategies for evolving road user patterns, with particular attention to increasing safety device usage and addressing the high mortality associated with severe RTIs are warranted.
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  • 文章类型: Journal Article
    背景:行人交通伤害是全球范围内日益增加的公共卫生问题。在沙特阿拉伯等快速城市化的国家,这些伤害占创伤病例的相当大比例,对医疗保健系统构成挑战。这项研究旨在分析关键特征,季节性,利雅得行人交通伤害的结果,沙特阿拉伯。
    方法:本研究是对沙特国王医疗城的所有行人交通伤害的回顾性队列分析,利雅得,并在2017年8月1日至2022年12月31日期间纳入沙特创伤登记处(STAR)数据库。度量和标称变量的分析报告为平均值(标准偏差,SD)或中位数(四分位距,IQR)和频率(%),分别。进行了逻辑回归分析,以检查患者院前生命体征和到达ED时的关键特征对机械通气需求和院内死亡率的影响。
    结果:在研究期间,1062名行人受伤患者被纳入分析,大多数是男性(89.45%),平均(SD)年龄为33.44(17.92)岁。三分之一(35.88%)的患者是沙特国民。三分之二(67.04%)的伤情发生在下午六时至上午六时,与其他年份相比,在COVID-19大流行期间(2020年)发现了较小百分比的伤害事件(13.28%)。一半(50.19%)的病人被红新月会救护车送往急诊科,19.68%需要插管和机械通气。大部分患者(87.85%)在完成治疗后已出院回家,我们队列的总死亡率为4.89%.logistic回归分析显示,患者院前生命体征和到达ED时的关键特征对机械通气需求(Chi2=161.95,p<0.001)和住院死亡率(Chi2=63.78,p<0.001)的整体影响显着。
    结论:本研究详细介绍了人口统计,temporal,以及沙特主要创伤中心行人交通伤害的临床趋势。识别高风险个体和受伤时机对于资源分配至关重要,针对道路安全干预措施,如公众意识运动和监管改革,改善院前护理和患者预后。
    BACKGROUND: Pedestrian traffic injuries are a rising public health concern worldwide. In rapidly urbanizing countries like Saudi Arabia, these injuries account for a considerable proportion of trauma cases and represent a challenge for healthcare systems. The study aims to analyze the key characteristics, seasonality, and outcomes of pedestrian traffic injuries in Riyadh, Saudi Arabia.
    METHODS: This study was a retrospective cohort analysis of all pedestrian traffic injuries presented to King Saud Medical City, Riyadh, and included in the Saudi Trauma Registry (STAR) database between August 1, 2017, and December 31, 2022. The analysis of metric and nominal variables was reported as mean (standard deviation, SD) or median (interquartile range, IQR) and frequencies (%), respectively. A logistic regression analysis was performed to examine the influence of patients\' pre-hospital vitals and key characteristics on arrival at the ED on the need for mechanical ventilation and in-hospital mortality.
    RESULTS: During the study period, 1062 pedestrian-injured patients were included in the analysis, mostly males (89.45%) with a mean (SD) age of 33.44 (17.92) years. One-third (35.88%) of the patients were Saudi nationals. Two-thirds (67.04%) of the injuries occurred from 6 p.m. until 6 a.m. Compared to other years, a smaller % of injury events (13.28%) were noticed during the COVID-19 pandemic (2020). Half (50.19%) of the patients were transported to the emergency department by the Red Crescent ambulance, and 19.68% required intubation and mechanical ventilation. Most of the patients (87.85%) were discharged home after completion of treatment, and our cohort had a 4.89% overall mortality. The logistic regression analysis showed the influence of patients\' pre-hospital vitals and key characteristics on arrival at the ED on the need for mechanical ventilation (Chi2 = 161.95, p < 0.001) and in-hospital mortality (Chi2 = 63.78, p < 0.001) as a whole significant.
    CONCLUSIONS: This study details the demographic, temporal, and clinical trends of pedestrian traffic injuries at a major Saudi trauma center. Identifying high-risk individuals and injury timing is crucial for resource allocation, targeting road safety interventions like public awareness campaigns and regulatory reforms, and improving prehospital care and patient outcomes.
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  • 文章类型: Journal Article
    背景:创伤在伊朗是一个重要的公共卫生问题,死亡率和发病率高。这项研究旨在评估沙鲁德创伤患者的概况,伊朗。研究设计:横断面研究。
    方法:该研究涉及在Shahroud的ImamHossein医院符合特定标准的创伤患者,伊朗,在2016年至2023年之间,使用伊朗国家创伤登记处(NTRI)。采用卡方检验和事后分析分析损伤特征与损伤原因的关系。Quintile回归模型评估了人口统计学和临床变量与住院时间的关联。
    结果:在3513例创伤患者中,与跌倒(0.3%)相比,格拉斯哥昏迷量表(GCS)中道路交通事故(RTC)的受伤比例在9~12(1.7%)之间(P<0.001).与RTC(17.1%)相比,跌倒引起的伤害严重程度评分(ISS)为9至15(22.7%)的中度病例更多(P<0.001)。与RTC相关的损伤需要更多的通气(2.7%)和重症监护病房(ICU)入院(11.1%),而不是跌倒(P<0.001)。在调整了年龄之后,GCS,ISS,和身体区域,跌倒的中位住院时间比RTC短9小时(95%CI=-16.2,-1.8).
    结论:在RTC和跌倒之间观察到了显著的损伤模式差异。RTC的损伤频率较高,导致GCS评分在9到12之间,而跌倒的ISS评分中等的频率较高。此外,RTC相关损伤患者需要更多的机械通气和ICU入住.此外,在对各种因素进行调整后,与跌倒相关损伤患者相比,RTC相关损伤患者的住院时间明显更长.
    BACKGROUND: Trauma is a significant public health concern in Iran, with high mortality and morbidity rates. This study aimed to assess trauma patients\' profiles in Shahroud, Iran. Study Design: A cross-sectional study.
    METHODS: The study involved trauma patients who met specific criteria at Imam Hossein hospital in Shahroud, Iran, between 2016 and 2023, using the National Trauma Registry of Iran (NTRI). The relationship between injury characteristics and the cause of injury was analyzed using chi-square test and post hoc analysis. Quintile regression models assessed the association of demographic and clinical variables with length of stay.
    RESULTS: Among 3513 trauma patients, road traffic crashes (RTCs) had a higher percentage of injuries with the Glasgow Coma Scale (GCS) between 9 and 12 (1.7%) compared to falls (0.3%) (P<0.001). Falls caused more moderate cases with injury severity scores (ISS) ranging from 9 to 15 (22.7%) than RTCs (17.1%) (P<0.001). RTC-related injuries required more ventilation (2.7%) and intensive care unit (ICU) admissions (11.1%) than falls (P<0.001). After adjusting for age, GCS, ISS, and body region, fall had a median length of stay nine hours shorter than RTCs (95% CI = -16.2, -1.8).
    CONCLUSIONS: Significant injury pattern differences were observed between RTCs and falls. RTCs had higher frequencies of injuries resulting in GCS scores between 9 and 12, while falls had higher frequencies of moderate ISS scores. In addition, patients with RTC-related injuries required more mechanical ventilation and ICU admissions. Moreover, after adjusting for various factors, patients with RTC-related injuries had a significantly longer hospital stay compared to those with fall-related injuries.
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  • 文章类型: Journal Article
    背景:在低收入和中等收入国家,职业性手和手腕受伤(OHWIs)占与工作有关的事故的25%。在哥伦比亚,2021年发生了超过50万起职业事故,尽管这一比率在2020年和2021年下降到不到5%,但至少有四分之一的事故涉及手或手腕受伤。
    目的:描述在哥伦比亚二级医院急诊室看到的工人中的OHWIs。
    方法:一项观察性研究使用来自经历OHWIs并在二级医院就诊的工人的数据进行,六月之间,2020年5月,2021年。OHWIs的总体频率,以及它们按社会人口统计的分布,临床,和职业变量,被描述。此外,性别之间的关联模式,解剖区域(手指,手,手腕),和工作类型进行了对应分析(CA)。
    结果:有2.101名工人因职业事故接受治疗,423例(20.3%)是OHWIs,主要影响男性(93.9%),中位年龄为31岁,主要在采矿业工作(75.9%)。OHWIs在右上肢更为常见(55.3%),包括不同类型的损伤,如挫伤(42.1%),裂伤(27.9%),骨折(18.7%),挤压伤(15.6%)。他们主要影响指骨(95.2%),尤其是第一个手指(25.7%)。CA显示受伤的解剖区域与工人的工作之间的关联在男性和女性中有所不同(解释方差>90%)。
    结论:昆迪纳马卡遭受职业事故的五分之一工人,哥伦比亚有一个OHWI,主要影响从事采矿的男性。这种职业特征很可能会导致长期康复,和永久性的功能限制。我们的结果可能有助于调整集群风险组的预防措施。
    BACKGROUND: Occupational hand and wrist injuries (OHWIs) account for 25% of work-related accidents in low- and middle-income countries. In Colombia, more than 500000 occupational accidents occurred in 2021, and although the rate declined to less than 5% in 2020 and 2021, at least one in four accidents involved a hand or wrist injury.
    OBJECTIVE: To describe the OHWIs in workers seen at the emergency room at a second-level hospital in Colombia.
    METHODS: An observational study was performed using data from workers who experienced OHWIs and attended a second-level hospital, between June, 2020 and May, 2021. The overall frequency of OHWIs, as well as their distribution by sociodemographic, clinical, and occupational variables, are described. Furthermore, association patterns between sex, anatomical area (fingers, hand, wrist), and type of job were analyzed by correspondence analysis (CA).
    RESULTS: There were 2.101 workers treated for occupational accidents, 423 (20.3%) were cases of OHWIs, which mainly affected men (93.9%) with a median age of 31 years and who worked mainly in mining (75.9%). OHWIs were more common in the right upper extremity (55.3%) and comprised different types of injuries, such as contusion (42.1%), laceration (27.9%), fracture (18.7%), and crush injury (15.6%). They primarily affected the phalanges (95.2%), especially those of the first finger (25.7%). The CAs showed associations between the injured anatomical area and the worker\'s job that differed in men and women (explained variance > 90%).
    CONCLUSIONS: One out of five workers who suffered occupational accidents in Cundinamarca, Columbia had an OHWI, affecting mainly males employed in mining. This occupational profile is likely to lead to prolonged rehabilitation, and permanent functional limitations. Our results might be useful for adjusting preventive measures in cluster risk groups.
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  • 文章类型: Journal Article
    洛哌丁胺,一种有效的μ阿片受体激动剂,用作止泻药,在超治疗剂量下表现出增加的生物利用度,造成潜在的中枢神经系统影响.滥用阿片类药物戒断和兴奋会导致危险的血液水平升高,导致严重的心律失常和死亡.这项研究旨在比较瑞典和芬兰的洛哌丁胺阳性尸检病例,重点关注洛哌丁胺在死亡中的作用,并确定受影响者的共同特征。包括瑞典(2012-2022年)和芬兰(2017-2022年)法医尸检中在股血液中检测到洛哌丁胺的所有病例。在瑞典,在126个人中检测到洛哌丁胺,在芬兰,111个人。在瑞典和芬兰,死后股骨血液中洛哌丁胺阳性的个体的发生率在研究期间稳步增加。仅在瑞典观察到与洛哌丁胺相关的死亡(n=80),主要涉及有药物滥用史的年轻男性,通常被归类为意外死亡。瑞典洛哌丁胺非相关死亡组反映了芬兰的全部病例。与洛哌丁胺(中位数0.080μg/g)的情况相比,在洛哌丁胺被认为是死亡原因的情况下(中位数0.140μg/g),死后股骨血液中的洛哌丁胺浓度显着升高,以及两个国家与洛哌丁胺无关的死亡(瑞典:中位数0.029μg/g;芬兰:中位数0.010μg/ml)。瑞典洛哌丁胺的定量上限可能会低估流行病学评估中的治疗使用者。这项研究强调了芬兰不存在洛哌丁胺滥用,并表明瑞典洛哌丁胺滥用的上升趋势。
    Loperamide, a potent μ-opioid receptor agonist used as an antidiarrheal drug, exhibits increased bioavailability at supratherapeutic doses, causing potential central nervous system effects. Its misuse for opioid withdrawal relief and euphoria can lead to dangerously elevated blood levels, causing severe cardiac dysrhythmias and death. This study aimed to compare loperamide positive autopsy cases in Sweden and Finland after the introduction of postmortem toxicological analysis of loperamide, focusing on loperamide\'s role in fatalities and identifying common characteristics among those affected. All cases with detected loperamide in femoral blood at forensic autopsies in Sweden (2012-2022) and Finland (2017-2022) were included. In Sweden, loperamide was detected in 126 individuals, and in Finland, in 111 individuals. The incidence of individuals positive for loperamide in postmortem femoral blood increased steadily over the study duration in both Sweden and Finland. Loperamide related fatalities were observed exclusively in Sweden (n=80), predominantly involving younger males with histories of substance abuse, typically classified as accidental deaths. The group of loperamide nonrelated deaths in Sweden mirrored the entirety of cases in Finland. The concentration of loperamide in postmortem femoral blood was significantly higher in cases where loperamide was considered the cause of death (median 0.140 μg/g) compared to cases where loperamide contributed (median 0.080 μg/g), as well as in deaths unrelated to loperamide in both countries (Sweden: median 0.029 μg/g; Finland: median 0.010 μg/ml). The high limit of quantification for loperamide in Sweden may underestimate therapeutic users in epidemiological assessments. This study underscores the absence of loperamide misuse in Finland and indicates a rising trend of loperamide abuse in Sweden.
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  • 文章类型: Journal Article
    目标:Seveso事故(1976年)在米兰以北地区造成了2,3,7,8-四氯二苯并对二恶英(TCDD)的污染,意大利。我们报告了截至2013年暴露人群死亡率和癌症发病率的最新结果。
    方法:研究队列包括生活在三个TCDD土壤浓度降低的污染区(A区,B和R)以及周围未受污染的区域(参考)。泊松模型分层/调整性别,对年龄和时期进行拟合以计算比率(RR)和95%CIs。
    结果:在男性的A区中,我们发现,在事故发生后的头十年中,循环系统疾病的死亡率上升(17人死亡,RR2.00,95%CI1.24至3.23)。在女性中,糖尿病死亡率增加,各地区都有积极的趋势。在最初的十年中,男性在R区的软组织肉瘤的发病率增加(6例,RR2.62,95%CI1.01至6.83)。在B区的女性中,30年后有过多的非霍奇金淋巴瘤(6例,RR2.87,95%CI1.14至7.23)。B区女性多发性骨髓瘤在第二个十年增加(4例,RR5.09,95%CI1.82至14.2),男性在R区(11例,RR2.15,95%CI1.08至4.26)。在R区的男性中,30年后出现白血病过度(23例,RR2.02,95%CI1.04至3.93)。
    结论:尽管不同性别的模式不同,地区和时间,我们证实了先前心血管疾病增加的结果,糖尿病,软组织肉瘤,以及淋巴癌和造血肿瘤。
    OBJECTIVE: The Seveso accident (1976) caused the contamination with 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) in an area north of Milan, Italy. We report the results of the update of mortality and cancer incidence in the exposed population through 2013.
    METHODS: The study cohort includes subjects living in three contaminated zones with decreasing TCDD soil concentrations (zone A, B and R) and in a surrounding uncontaminated territory (reference). Poisson models stratified/adjusted for gender, age and period were fitted to calculate rate ratios (RRs) and 95% CIs.
    RESULTS: In zone A in males, we found elevated mortality from circulatory diseases in the first decade after the accident (17 deaths, RR 2.00, 95% CI 1.24 to 3.23). In females, mortality from diabetes mellitus was increased, with a positive trend across zones. Incidence of soft tissue sarcoma was increased in males in zone R in the first decade (6 cases, RR 2.62, 95% CI 1.01 to 6.83). In females in zone B, there was an excess of non-Hodgkin\'s lymphoma after 30 years (6 cases, RR 2.87, 95% CI 1.14 to 7.23). Multiple myeloma was increased in the second decade in females in zone B (4 cases, RR 5.09, 95% CI 1.82 to 14.2) and in males in zone R (11 cases, RR 2.15, 95% CI 1.08 to 4.26). In males in zone R, there was a leukaemia excess after 30 years (23 cases, RR 2.02, 95% CI 1.04 to 3.93).
    CONCLUSIONS: Although with different patterns across gender, zone and time, we confirmed previous results of increased cardiovascular diseases, diabetes, soft tissue sarcoma, and lymphatic and haematopoietic cancers.
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  • 文章类型: Journal Article
    对受伤的潜水员进行评估和护理需要了解可能被视为水肺潜水的不同类型的水下活动。这些活动可能从复杂的范围(例如,商业或技术潜水)一直到基本的娱乐性水肺或浮潜。应尽早完成全面的身体检查,重点是有受伤风险和病因的特定区域。比如详细的心肺,皮肤,和神经系统检查。系列重新评估和支持性护理与咨询潜水医学专家同样重要,尤其是有高压能力的人.
    The evaluation and care of an injured scuba diver requires an understanding of the different types of underwater activities that may be deemed scuba diving. Such activities may range from the complex (eg, commercial or technical diving) all the way up to basic recreational scuba or snorkeling. A thorough physical examination should be completed as early as possible with a focus on specific areas at risk for injury and etiology, such as a detailed cardiopulmonary, skin, and neurologic examination. Serial reassessments and supportive care are as equally important as consultation with a dive medicine expert, especially one with hyperbaric capabilities.
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