■在黑素瘤2(AIM2)中缺失与炎症过程有关。我们测量了血清AIM2,旨在揭示其对急性脑出血(ICH)后卒中相关性肺炎(SAP)和功能预后的预测意义。
■在这项前瞻性队列研究中,163例ICH患者在入院时测定血清AIM2浓度,其中57例患者也同意在第1,3,5,7,10和14天进行测定.加上57名没有健康状况的人,发现血清AIM2水平的动态变化。美国国立卫生研究院卒中量表(NIHSS)评分和血肿体积被确定为严重程度的双重指标。卒中后六个月改良的Rankin量表(mRS)评分范围为3至6,表明预后不良。在ICH后的前7天期间观察到SAP。进行顺序单变量和多变量分析以辨别SAP和不良预后的预测因子。
■患者入院时血清AIM2水平明显升高,在第三和第五天达到峰值水平,与对照组相比,直到第14天仍然显着升高。血清AIM2水平与NIHSS评分和血肿体积均呈独立相关性。此外,AIM2浓度与6个月时的不良预后和SAP独立相关。在受限三次样条分析的框架内,血清AIM2浓度与发生SAP和预后不良的可能性呈线性关系.在接收器工作特性(ROC)曲线分析的背景下,血清AIM2浓度可有效区分SAP的风险和不良预后。通过采用分段分析,血清AIM2浓度与几个传统变量的相互作用可忽略不计,比如年龄,性别,吸烟习惯,酒精消费,还有更多.纳入血清AIM2、NIHSS评分、通过列线图描绘血肿体积,并在各种评估指标中对不良预后或SAP表现出强大的预测能力,包括ROC曲线分析,校正曲线分析,和决策曲线分析。
■脑出血(ICH)后不久,血清AIM2水平显着增加,这可以准确反映中风的严重程度,并有效预测SAP和不良的神经系统结果,因此,血清AIM2作为ICH的一个令人鼓舞的预测指标。
UNASSIGNED: Absent in melanoma 2 (AIM2) is implicated in inflammatory processes. We measured serum AIM2 with intent to unveil its predictive significance for stroke-associated pneumonia (SAP) and functional prognosis following acute intracerebral hemorrhage (ICH).
UNASSIGNED: In this prospective cohort study, serum AIM2 concentrations of 163 ICH patients were gauged upon admission and 57 of them also consented for measurements at days 1, 3, 5, 7, 10 and 14. Coupled with 57 individuals without health conditions, dynamic change of serum AIM2 levels were uncovered. National Institutes of Health Stroke Scale (NIHSS) scores and hematoma volume were identified as the dual indicators of severity. Poststroke six-month modified Rankin Scale (mRS) scores ranging from 3 to 6 indicated an unfavorable outcome. SAP was observed during the first seven days after ICH. Sequential univariate and multivariate analyses were performed to discern predictors of SAP and adverse prognosis.
UNASSIGNED: The serum levels of AIM2 in patients exhibited a marked elevation upon admission, reaching peak levels on the third and fifth days, and remained notably elevated until day 14 compared to those of the control group. Serum AIM2 levels showed independent correlations with both NIHSS scores and the volume of hematoma. Additionally, AIM2 concentrations were independently associated with a poor prognosis and SAP at the six-month mark. Within the framework of restricted cubic spline analysis, serum AIM2 concentrations exhibited a linear correlation with the likelihood of developing SAP and experiencing a poor prognosis. In the context of receiver operating characteristic (ROC) curve analysis, serum AIM2 concentrations effectively differentiated risks of SAP and poor prognosis. By employing segmented analysis, serum AIM2 concentrations showed negligible interactions with several traditional variables, such as age, gender, smoking habits, alcohol consumption, and more. The integrated model incorporating serum AIM2, NIHSS scores, and the volume of hematoma was depicted by employing a nomogram and demonstrated strong predictive performance for poor prognosis or SAP across various evaluation metrics, including ROC curve analysis, calibration curve analysis, and decision curve analysis.
UNASSIGNED: Serum AIM2 levels show a marked increase shortly after intracerebral hemorrhage (ICH), which may accurately reflect stroke severity, and effectively predict SAP and poor neurological outcomes, and therefore serum AIM2 stands out as an encouraging predictive indicator for ICH.