Abstract：
BACKGROUND: Absent in melanoma 2 (AIM2) participates in neuroinflammation. Here, the prognostic significance of serum AIM2 was explored in severe traumatic brain injury (sTBI).
METHODS: A total of 135 sTBI patients and 80 healthy controls were recruited in this prospective cohort study. Serum C-reactive protein (CRP) and AIM2 levels were measured. Glasgow Coma Scale (GCS) and Rotterdam computed tomography (CT) classification were recorded as the severity indicators. Prognostic parameters were posttraumatic six-month extended Glasgow outcome scale (GOSE) scores and poor outcome (GOSE scores of 1-4).
RESULTS: As opposed to controls, there were significantly elevated serum AIM2 levels after sTBI. Serum AIM2 levels were independently correlated with serum CRP levels, GCS scores, Rotterdam CT scores, GOSE scores and poor outcome. Also, serum AIM2 levels were efficiently predictive of poor outcome under the receiver operating characteristic (ROC) curve. Under the restricted cubic spline, serum AIM2 levels were linearly correlated with risk of poor outcome. Using subgroup analysis, serum AIM2 levels did not significantly interact with other indices, such as age, gender, alcohol drinking, cigarette smoking, etc. Also, combination model, in which serum AIM2, GCS scores and Rotterdam CT scores were merged, was outlined using nomogram and performed well under calibration curve, ROC curve and decision curve.
CONCLUSIONS: Raised serum AIM2 levels after sTBI, in intimate correlation with systemic inflammation and trauma severity, are independently discriminative of posttraumatic six-month neurological outcome, substantializing serum AIM2 as an inflammatory prognostic biomarker of sTBI.
METHODS: A total of 135 sTBI patients and 80 healthy controls were recruited in this prospective cohort study. Serum C-reactive protein (CRP) and AIM2 levels were measured. Glasgow Coma Scale (GCS) and Rotterdam computed tomography (CT) classification were recorded as the severity indicators. Prognostic parameters were posttraumatic six-month extended Glasgow outcome scale (GOSE) scores and poor outcome (GOSE scores of 1-4).
RESULTS: As opposed to controls, there were significantly elevated serum AIM2 levels after sTBI. Serum AIM2 levels were independently correlated with serum CRP levels, GCS scores, Rotterdam CT scores, GOSE scores and poor outcome. Also, serum AIM2 levels were efficiently predictive of poor outcome under the receiver operating characteristic (ROC) curve. Under the restricted cubic spline, serum AIM2 levels were linearly correlated with risk of poor outcome. Using subgroup analysis, serum AIM2 levels did not significantly interact with other indices, such as age, gender, alcohol drinking, cigarette smoking, etc. Also, combination model, in which serum AIM2, GCS scores and Rotterdam CT scores were merged, was outlined using nomogram and performed well under calibration curve, ROC curve and decision curve.
CONCLUSIONS: Raised serum AIM2 levels after sTBI, in intimate correlation with systemic inflammation and trauma severity, are independently discriminative of posttraumatic six-month neurological outcome, substantializing serum AIM2 as an inflammatory prognostic biomarker of sTBI.
摘要：
背景：在黑色素瘤中缺失2（AIM2）参与神经炎症。这里,探讨血清AIM2在重型颅脑损伤（sTBI）中的预后意义。
方法：这项前瞻性队列研究共招募了135例sTBI患者和80例健康对照。检测血清C反应蛋白(CRP)和AIM2水平。记录格拉斯哥昏迷量表（GCS）和鹿特丹计算机断层扫描（CT）分类作为严重程度指标。预后参数为创伤后六个月延长的格拉斯哥结果量表（GOSE）评分和不良结果（GOSE评分为1-4）。
结果：与对照相比，sTBI后血清AIM2水平显著升高。血清AIM2水平与血清CRP水平独立相关,GCS分数,鹿特丹CT评分,GOSE分数和不良结果。此外，血清AIM2水平可有效预测受试者工作特征（ROC）曲线下的不良预后。在受限三次样条下，血清AIM2水平与不良预后风险呈线性关系.使用亚组分析，血清AIM2水平与其他指标无显著交互作用，比如年龄,性别,饮酒,吸烟,等。此外，组合模型，合并血清AIM2、GCS评分和鹿特丹CT评分，使用列线图进行了概述，并在校准曲线下表现良好，ROC曲线和决策曲线。
结论：sTBI后血清AIM2水平升高，与全身炎症和创伤严重程度密切相关，独立区分创伤后六个月的神经系统结果，证实血清AIM2作为sTBI的炎性预后生物标志物。
方法：这项前瞻性队列研究共招募了135例sTBI患者和80例健康对照。检测血清C反应蛋白(CRP)和AIM2水平。记录格拉斯哥昏迷量表（GCS）和鹿特丹计算机断层扫描（CT）分类作为严重程度指标。预后参数为创伤后六个月延长的格拉斯哥结果量表（GOSE）评分和不良结果（GOSE评分为1-4）。
结果：与对照相比，sTBI后血清AIM2水平显著升高。血清AIM2水平与血清CRP水平独立相关,GCS分数,鹿特丹CT评分,GOSE分数和不良结果。此外，血清AIM2水平可有效预测受试者工作特征（ROC）曲线下的不良预后。在受限三次样条下，血清AIM2水平与不良预后风险呈线性关系.使用亚组分析，血清AIM2水平与其他指标无显著交互作用，比如年龄,性别,饮酒,吸烟,等。此外，组合模型，合并血清AIM2、GCS评分和鹿特丹CT评分，使用列线图进行了概述，并在校准曲线下表现良好，ROC曲线和决策曲线。
结论：sTBI后血清AIM2水平升高，与全身炎症和创伤严重程度密切相关，独立区分创伤后六个月的神经系统结果，证实血清AIM2作为sTBI的炎性预后生物标志物。
