铜是原子转移自由基聚合(ATRP)中最常用的金属催化剂,但铁是一个很好的替代品,因为它的天然丰度和低毒性相比,铜。在这项工作中,受天然蛋白质启发的两种新的铁卟啉基催化剂,如辣根过氧化物酶,血红蛋白,和细胞色素P450合成并测试ATRP。通过将咪唑或硫醚基团连接到卟啉来模拟天然蛋白质结构,导致聚合速率增加,以及提供低分散性的聚合物,即使在ppm量的催化剂存在。
Copper is the most common metal catalyst used in atom transfer radical polymerization (ATRP), but iron is an excellent alternative due to its natural abundance and low toxicity compared to copper. In this work, two new iron-porphyrin-based catalysts inspired by naturally occurring proteins, such as horseradish peroxidase, hemoglobin, and cytochrome P450, were synthesized and tested for ATRP. Natural protein structures were mimicked by attaching imidazole or thioether groups to the porphyrin, leading to increased rates of polymerization, as well as providing polymers with low dispersity, even in the presence of ppm amounts of catalysts.