多巴胺受体D2(DRD2)和锚蛋白重复序列和含激酶结构域的蛋白1(ANKK1)基因因参与酒精使用障碍(AUD)而受到广泛关注。但是他们的确切角色仍然存在许多问题。我们在大量的年轻人样本中进行了基于人群的病例对照和遗传关联研究。我们的目的是评估DRD2和ANKK1单核苷酸多态性(SNP)与有害酒精使用之间的关联。解开相关和可能的中间因素。共有1841名来自法国香槟-阿登地区的大学生,年龄在18至21岁之间,并且报告至少一生饮酒一次,包括在这项研究中。根据有害酒精使用(通过酒精使用障碍鉴定测试[AUDIT]问卷评估)分析等位基因频率。不同的物质使用障碍,包括尼古丁和大麻的依赖性,还通过问卷调查进行了评估,以及一系列潜在的相关因素(例如,重度抑郁发作,行为障碍,注意缺陷/多动障碍[ADHD],学校失败,糖消耗,性创伤,父母使用酒精,烟草或大麻)。我们发现DRD2rs1800498与有害酒精使用有关。检测到许多因素,但一项全球路径分析显示,DRD2rs1800498对有害酒精使用有显著的直接影响,初次饮酒时年龄较早和抑郁症状缓解了这种影响.这项研究表明,有害酒精使用之间存在相互作用,DRD2基因型和其他危险因素,有了充分的理解,可能有助于预防。
Dopamine receptor D2 (DRD2) and ankyrin repeat and kinase domain-containing protein 1 (ANKK1) genes have received considerable attention for their involvement in alcohol use disorder (AUD), but many questions remain on their exact role. We conducted a population-based case-control and genetic association study in a large sample of young adults. Our aim was to assess the association between DRD2 and ANKK1 single nucleotide polymorphisms (SNPs) and harmful alcohol use, disentangling associated and possible intermediate factors. A total of 1841 college students from the French region Champagne-Ardennes, aged between 18 and 21 years and who reported at least one lifetime alcohol consumption, were included in this study. Allele frequencies were analysed according to harmful alcohol use (assessed through the Alcohol Use Disorder Identification Test [AUDIT] questionnaire). Different substance use disorders, including nicotine and cannabis dependences, were also assessed through questionnaires, as was a list of potential associated factors (e.g., major depressive episode, conduct disorder, attention-deficit/hyperactivity disorder [ADHD], school failure, sugar consumption, sexual trauma, parents\' use of alcohol, tobacco or cannabis). We found that DRD2 rs1800498 was associated with harmful alcohol use. Many factors were detected, but a global path analysis revealed that DRD2 rs1800498 had a significant direct effect on harmful alcohol use and that early age at first alcohol consumption and depressive symptoms moderated this effect. This study suggests an interplay between harmful alcohol use, DRD2 genotypes and other risk factors that, with a full understanding, could be useful for preventive purposes.