%0 Journal Article
%T Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population.
%A Genis-Mendoza AD
%A López-Narvaez ML
%A Tovilla-Zárate CA
%A Sarmiento E
%A Chavez A
%A Martinez-Magaña JJ
%A González-Castro TB
%A Hernández-Díaz Y
%A Juárez-Rojop IE
%A Ávila-Fernández Á
%A Nicolini H
%J Neuropsychobiology
%V 76
%N 4
%D 2017
%M 29966133
%F 12.329
%R 10.1159/000490071
%X <B>BACKGROUND: </B>The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population.<BR><B>METHODS: </B>We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models.<BR><B>RESULTS: </B>Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56-5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37-5.75) as well as males (OR = 3.3; 95% CI 1.01-10.77).<BR><B>CONCLUSIONS: </B>Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.