冠状动脉疾病(CAD)是印度的主要死亡原因。许多基因多态性在调节氧化应激中起作用,血压和脂质代谢,有助于CAD的病理生理学。这项研究检查了印度北部JatSikh人群中十个多态性与CAD之间的关联,还考虑了多基因风险评分。这项研究包括177例CAD病例和175例健康对照。GSTM1的遗传信息(rs366631),GSTT1(rs17856199),ACE(rs4646994),AGTM235T(rs699),AGTT174M(rs4762),AGTR1A1166C(rs5186),APOA5(rs3135506),APOC3(rs5128),对APOE(rs7412)和APOE(rs429358)的临床资料进行整理。使用SPSS版本27.0和SNPstats进行统计分析。发现GST*M1、GST*T1、ACE、AGTM235T,AGTT174M,AGTR1A1166C和APOA5多态性与CAD风险(均p<0.05)。AGTCT单倍型与更高的CAD风险显著相关,即使在控制协变量之后(调整后的OR=3.93,95%CI[2.39-6.48],p<0.0001)。APOA5/C3CC单倍型也与CAD显著相关(校正OR=1.86,95%CI[1.14-3.03],p<0.05)。较高的多基因风险评分与CAD风险增加相关(校正OR=1.98,95%CI[1.68-2.34],p<0.001)。在这个北印度人群中,七个多态性与CAD风险的增加独立相关。AGT的相当大的风险关联,APOA5/C3单倍型和更高的遗传风险评分被记录,这可能对临床和公共卫生应用有影响。
Coronary artery disease (CAD) is the leading cause of death in India. Many genetic polymorphisms play a role in regulating oxidative stress, blood pressure and lipid metabolism, contributing to the pathophysiology of CAD. This study examined the association between ten polymorphisms and CAD in the Jat Sikh population from Northern India, also considering polygenic risk scores. This study included 177 CAD cases and 175 healthy controls. The genetic information of GSTM1 (rs366631), GSTT1 (rs17856199), ACE (rs4646994), AGT M235T (rs699), AGT T174M (rs4762), AGTR1 A1166C (rs5186), APOA5 (rs3135506), APOC3 (rs5128), APOE (rs7412) and APOE (rs429358) and clinical information was collated. Statistical analyses were performed using SPSS version 27.0 and SNPstats. Significant independent associations were found for GST*M1, GST*T1, ACE, AGT M235T, AGT T174M, AGTR1 A1166C and APOA5 polymorphisms and CAD risk (all p < 0.05). The AGT CT haplotype was significantly associated with a higher CAD risk, even after controlling for covariates (adjusted OR = 3.93, 95% CI [2.39-6.48], p < 0.0001). The APOA5/C3 CC haplotype was also significantly associated with CAD (adjusted OR = 1.86, 95% CI [1.14-3.03], p < 0.05). A higher polygenic risk score was associated with increased CAD risk (adjusted OR = 1.98, 95% CI [1.68-2.34], p < 0.001). Seven polymorphisms were independently associated with an increase in the risk of CAD in this North Indian population. A considerable risk association of AGT, APOA5/C3 haplotypes and higher genetic risk scores is documented, which may have implications for clinical and public health applications.