Abstract：
The aetiological mechanism of preeclampsia (PE) is unclear exactly, so we attempted to investigate the association between susceptibility to preeclampsia and renin-angiotensin-aldosterone system (RAAS) gene polymorphisms to explore the aetiology in terms of genetics. A systematic search was performed in electronic databases to identify relevant studies. Eventually 73 studies were enrolled, odds ratios were generated by 5 genetic models. In overall analysis, significant associations were detected for AGT M235T, AT1R A1166C and CYP11B2 C344T whereas negative correlation was shown for AGT T174M. As stratified by race and geography, AGT 235T allele and AT1R 1166C allele increased preeclampsia risk and AGT T174M was justified uncorrelated with preeclampsia. Our meta-analysis illustrated that AGT 235T allele and AT1R 1166C allele increased and CYP11B2 344T allele decreased preeclampsia risk while AGT T174M polymorphism did not change preeclampsia risk. Hence, pregnant women carrying high-risk genotypes need strengthened management to prevent and early identification of preeclampsia.
摘要：
子痫前期（PE）的病因机制尚不清楚，因此，我们试图研究先兆子痫易感性与肾素-血管紧张素-醛固酮系统（RAAS）基因多态性之间的关联，以从遗传学角度探讨其病因。在电子数据库中进行了系统搜索，以确定相关研究。最终纳入了73项研究，优势比由5个遗传模型生成.在总体分析中，AGTM235T检测到显著关联，AT1RA1166C和CYP11B2C344T，而AGTT174M则呈负相关。按种族和地理分层，AGT235T等位基因和AT1R1166C等位基因增加先兆子痫风险，AGTT174M与先兆子痫无关。我们的荟萃分析表明，AGT235T等位基因和AT1R1166C等位基因增加，CYP11B2344T等位基因降低了先兆子痫的风险，而AGTT174M多态性并未改变先兆子痫的风险。因此，携带高危基因型的孕妇需要加强管理，以预防和早期识别先兆子痫。
