目的:痤疮患者通常会出现痤疮疤痕,疤痕的早期干预在痤疮管理中至关重要。1927nm激光激光(TFL)可有效改善疤痕,含30%超分子水杨酸(SSA)的化学剥离可用于治疗痤疮。这项研究的目的是评估和比较TFL单一疗法与同时应用TFL和30%SSA对痤疮和痤疮疤痕的疗效和安全性。
方法:纳入33例痤疮和痤疮疤痕患者,并且面部的两侧被随机分成以接受TFL和SSA化学剥离或TFL。双方均以4周的间隔进行了4次TFL治疗,SSA联合治疗侧另外接受8次SSA化学剥离,间隔2周。GAGS,ECCA评分,痤疮病变的数量,黑色素指数(MI)和红斑指数(EI),经皮水分流失(TEWL),在第0、4、8、12和18周记录副作用。在研究结束时记录患者的满意度。
结果:30名患者完成了研究。对照组(TFL单药)和SSA组(TFL联合SSA化学剥离)均显着改善了GAGS和ECCA评分。SSA组在GAGS和ECCA评分方面显示出更高的疗效,痤疮病变计数,TEWL,MI,EI,且满意度高于对照组。所有的副作用都是暂时的,可以忍受,未观察到不良反应.
结论:TFL和TFL联合30%SSA化学剥皮治疗和预防痤疮和痤疮疤痕是安全有效的。虽然联合组有较高的疗效。
OBJECTIVE: Patients with acne usually develops acne scars subsequently, early intervention of scars is crucial in acne management. 1927nm fractional thulium fiber laser (TFL) is effective in scars improvement and chemical peels with 30% supramolecular salicylic acid (SSA) can be applied for the treatment of acne. The purpose of this study is to evaluate and compare the efficacy and safety of TFL monotherapy versus the concomitant application of TFL and 30% SSA on acne and acne scars.
METHODS: Thirty-three patients with acne and acne scars were enrolled, and two sides of the face were randomly divided to receive either TFL and SSA chemical peeling or TFL. Four sessions of TFL treatments were applied with 4-week intervals for both sides, SSA combined treatment side received eight SSA chemical peels with 2-week intervals additionally. GAGS, ECCA score, the number of acne lesions, melanin index (MI) and erythema index (EI), transepidermal water loss (TEWL), and side effects were recorded at Weeks 0, 4, 8, 12, and 18. Satisfaction of patients was recorded on both sides at the end of the study.
RESULTS: Thirty patients completed the study. Both control group (TFL monotherapy) and SSA group (TFL combined with SSA chemical peeling) significantly improved GAGS and ECCA score. SSA group showed higher efficacy in terms of GAGS and ECCA score, acne lesion count, TEWL, MI, EI, and satisfaction than control group. All the side effects were temporary and tolerable, no adverse effects were observed.
CONCLUSIONS: Both TFL and the TFL combined with 30% SSA chemical peeling are safe and effective for the treatment and prevention of acne and acne scars, though the combined group has higher efficacy.