UNASSIGNED: To evaluate and compare the efficacy and safety profile of topical 20% glycolic acid and 30% salicylic acid in the treatment of MC in pediatric patients.
UNASSIGNED: All patients of MC between 1 and 15 years of age attending the outpatient department of dermatology were randomized into two treatment groups A and B. Group A was treated with 20% glycolic acid solution, and group B was treated with 30% salicylic acid solution daily for 4 weeks. Parents of patients were instructed to apply the medication once daily at night for 1 h on the lesions only. The assessment of response and side effects were analyzed in all the patients weekly for 4 weeks during the daily treatment protocol. Follow-up was done monthly for 3 months after the completion of therapy.
UNASSIGNED: At the end of 4 weeks, group A patients (60 patients) were treated with 20% glycolic acid out of which 34 (56.66%) patients had a complete clearance of lesions. Group B patients were treated with 30% salicylic acid out of which 38 (63.33%) had a complete clearance of lesions. Secondary bacterial infection was the most common side effect followed by postinflammatory hyperpigmentation in both groups.
UNASSIGNED: 30% salicylic acid was found to be more effective and has less side-effect profile in the treatment of MC than 20% glycolic acid.
UNASSIGNED:评估和比较20%乙醇酸和30%水杨酸局部治疗小儿MC的疗效和安全性。
UNASSIGNED:将所有1至15岁的MC患者随机分为A和B两个治疗组。A组用20%乙醇酸溶液治疗,B组每日给予30%水杨酸溶液治疗4周。指示患者的父母每天一次晚上仅在病变上施用药物1小时。在每日治疗方案期间,每周对所有患者进行4周的反应和副作用评估。治疗结束后每月随访3个月。
未经评估:在4周结束时,A组患者(60例)接受20%的乙醇酸治疗,其中34例(56.66%)患者的病变完全清除。B组患者接受30%水杨酸治疗,其中38例(63.33%)的病变完全清除。在两组中,继发细菌感染是最常见的副作用,其次是炎症后色素沉着过度。
UNASSIGNED:发现30%水杨酸比20%乙醇酸更有效,并且在MC的治疗中副作用更少。