背景:要评估第二到第四位数字比率(2D:4D)的关系,产前性激素暴露的生物标志物,腕部比率(WR),腕掌比(WPR),体重指数(BMI),腰臀比(WHR),不同腕管综合征(CTS)严重程度的握力(HGS)。
方法:本研究涉及90名患有CTS的女性参与者(年龄18至83岁)。根据CTS的严重性,参与者分为四组:正常,温和,中度,和严重。测量了手部人体测量和体脂分布的所有参数,和平均2D:4D,WR,WPR,HGS,BMI,根据CTS严重程度比较WHR值。使用疼痛的视觉模拟量表(VAS)和麻木严重程度的李克特(LS)量表收集数据。
结果:平均年龄,2D:4D,WD,WW,WR,WPR,BMI,和HGS值显示CTS严重程度组之间存在显着差异。我们发现,在消除年龄影响后,较低的2D:4D和较高的WPR和BMI与CTS风险增加相关(AUC=0.728)。38.9%(70/180)的参与者双手受到影响。回归分析表明,较低的HGS可以作为预测双侧受累手的女性的自变量。重度和中度组的LS评分明显更高。此外,重症组的VAS评分明显较高.
结论:研究结果表明2D:4D之间存在关联,WPR,女性的BMI,强调子宫内性激素暴露对晚年CTS严重程度的影响。
BACKGROUND: To evaluate the relationship of the second to fourth digit ratio (2D:4D), a biomarker of prenatal sex hormone exposure, with wrist ratio (WR), wrist-palm ratio (WPR), body mass index (BMI), waist-hip ratio (WHR), and handgrip strength (HGS) in different carpal tunnel syndrome (CTS) severity.
METHODS: This study involved 90 female participants (aged 18 to 83) with CTS. According to CTS severity, the participants were divided into four groups: normal, mild, moderate, and severe. All parameters of hand anthropometry and body fat distribution were measured, and the mean 2D:4D, WR, WPR, HGS, BMI, and WHR values were compared based on CTS severity. Data were collected with a visual analog scale (VAS) for pain and a Likert (LS) scale for numbness severity.
RESULTS: The mean age, 2D:4D, WD, WW, WR, WPR, BMI, and HGS values showed a significant differences between CTS severity groups. We found that lower 2D:4D and higher WPR and BMI were associated with increased risk of CTS (AUC = 0.728) after removing the effect of age. Bilateral hands were affected in 38.9 % (70/180) of participants. Regression analysis showed that lower HGS can be used as independent variable for predicting the females having bilateral affected hands. The LS score was considerably higher in the severe and moderate groups. Also, the VAS score was significantly higher in the severe group.
CONCLUSIONS: The findings of the study demonstrated an association between 2D:4D, WPR, and BMI among women, emphasizing the effect of intrauterine sex hormone exposure on late life CTS severity.