背景:甲状腺功能亢进猫通常患有全身性高血压,报告的患病率为7%至48%。尽管一旦治疗恢复甲状腺功能正常,高血压可能会消退,它可以持续或仅在治疗后首先发展。
目的:为了确定甲状腺功能亢进猫合并高血压(收缩压[SBP]≥160mmHg)的比例,成功的放射性碘治疗后高血压的持续或首次发展,以及治疗后高血压与氮质血症或甲状腺功能减退的相关性。
方法:本研究纳入了400只甲状腺功能亢进的非氮血症猫。
方法:前瞻性,横断面和前后研究。所有甲状腺功能亢进的猫都通过多普勒测量了SBP;成功的放射性碘(131I)治疗6个月后,有255例进行了SBP检查。
结果:在未经治疗的甲状腺功能亢进猫中,108/401(27%)为高血压。与血压正常的猫相比,高血压猫的神经/兴奋比例更高(47%vs12%;P<.001)。在最初的高血压猫中,131I治疗后,对87/108只猫进行了重新检查;43/87(49%)猫使SBP正常化,而44/87(51%)仍然是高血压。在最初血压正常的猫中,16/168(9.5%)在成功的131I治疗后首次出现高血压。131只I治疗的高血压猫中有7/60(12%)是氮血症,而9/60(15%)是甲状腺功能减退。保持高血压状态的猫比血压正常的猫有更高的比例(50%vs17%;P<.001)。
结论:高血压,当存在时,在成功治疗后,许多甲状腺功能亢进的猫。甲状腺功能亢进猫在治疗后罕见地发展为新的高血压。持续或新发现的高血压与氮质血症或医源性甲状腺功能减退无关。放射性碘治疗的高血压猫更频繁地感觉到紧张/焦虑,这表明这些猫中的许多可能患有“情境性”高血压,甲状腺功能亢进引起的高血压在治疗后应得到解决。
BACKGROUND: Hyperthyroid cats commonly have systemic hypertension, with a reported prevalence of 7% to 48%. Although hypertension might be expected to resolve once treatment restores euthyroidism, it can persist or only first develop after treatment.
OBJECTIVE: To determine the proportion of hyperthyroid cats with hypertension (systolic blood pressure [SBP] ≥160 mm Hg), persistence or first development of hypertension after successful radioiodine treatment, and correlation of post-treatment hypertension with azotemia or hypothyroidism.
METHODS: Four hundred one hyperthyroid nonazotemic cats were included in the study.
METHODS: Prospective, cross-sectional and before-and-after studies. All hyperthyroid cats had SBP measured by Doppler; 255 had SBP rechecked 6 months after successful radioiodine (
131I) treatment.
RESULTS: Of untreated hyperthyroid cats, 108/401 (27%) were hypertensive. A higher proportion of hypertensive cats were nervous/excited compared with normotensive cats (47% vs 12%; P < .001). Of the initially hypertensive cats, 87/108 cats were reexamined after
131I treatment; 43/87 (49%) cats normalized SBP, whereas 44/87 (51%) remained hypertensive. Of the initially normotensive cats, 16/168 (9.5%) first developed hypertension after successful
131I treatment. 7/60 (12%) of the
131I-treated hypertensive cats were azotemic and 9/60 (15%) were hypothyroid. A higher proportion of cats remaining hypertensive had nervous/excited demeanor than did normotensive cats (50% vs 17%; P < .001).
CONCLUSIONS: Hypertension, when present, resolves in many hyperthyroid cats after successful treatment. Hyperthyroid cats uncommonly develop new hypertension after treatment. Persistent or newly detected hypertension was unrelated to azotemia or iatrogenic hypothyroidism. More frequently perceived nervousness/anxiety in radioiodine-treated hypertensive cats suggests that many of these cats might have \"situational\" hypertension, as hyperthyroid-induced hypertension should resolve after treatment.