我们研究了Dohan的假设,即精神分裂症与麸质和酪蛋白中所含的“exphorphins”的吸收有关。此外,因为Reichelt等人的工作。(雷希特,K.L.,Saelid,G.,Lindback,J.和Orbeck,H.(1986)生物精神病学21:1279-1290)和Rodriguez等人。(罗德里格斯,Trav,A.L.,巴雷罗·马林,R,Galvez,Borrero,I.M.,delOlmoRomero-Nieva,F.和DiazAlvarez,A.(1994)神经和精神疾病杂志8月;182(8):478-479),我们对一组自闭症儿童进行了类似的研究。在这两种综合征中,我们发现在用SephadexG-15进行分子筛选后,含肽峰的模式相似(Ninhydin阳性)。对血清中的IgA和IgG进行抗麦醇溶蛋白和酪蛋白的免疫球蛋白测定。在87%的自闭症患者和86%的精神分裂症患者中发现了高滴度的麦醇溶蛋白IgG抗体,在90%的自闭症患者和93%的精神分裂症患者中发现了高滴度的牛酪蛋白IgG抗体。在30%的自闭症儿童中发现了高滴度的针对麸质或酪蛋白的IgA抗体,而在精神分裂症患者中,有86%的针对麸质的IgA抗体升高,而有67%的针对酪蛋白的IgA抗体升高;一些正常儿童和成人具有这些抗体,但只有痕量。当精神分裂症患者接受透析或无麸质酪蛋白饮食治疗时,或两者(凯德,R、Wagemaker,H.,Privette,R.M.,Fregly,M、罗杰斯,J.和奥兰多,J.(1990)精神病学:世界范围1:494-500)肽缺乏症和简短的精神病学评分评分下降,而异常行为减少。在大多数行为类别的3个月内,无麸质酪蛋白饮食伴随着81%的自闭症儿童的改善。我们的数据为以下提议提供了支持:许多精神分裂症或自闭症患者由于吸收了麸质和酪蛋白的不完全消化而在肠道中形成的外啡肽而遭受痛苦。
We examined Dohan\'s hypothesis that schizophrenia is associated with the absorption of \"exorphins\" contained in gluten and casein. In addition, because of the work of Reichelt et al. (Reichelt, K.L., Saelid, G., Lindback, J. and Orbeck, H. (1986) Biological Psychiatry 21:1279-1290) and Rodriguez et al. (Rodriguez, Trav, A.L., Barreiro Marin, R, Galvez, Borrero, I.M., del Olmo Romero-Nieva, F. and Diaz Alvarez, A. (1994) Journal of Nervous and Mental Disease Aug; 182(8): 478-479), we carried out similar studies on a group of children with autism. In both syndromes we found similar patterns of peptide containing peaks (Ninhydrin positive) after molecular screening with Sephadex G-15. Immunoglobulin assay of IgA and IgG against gliadin and casein in serum was done. High titer IgG antibodies to gliadin were found in 87% of autistic and 86% of schizophrenic patients and high titer IgG antibodies to bovine casein were found in 90% of autistic and in 93% of schizophrenic patients. High titer IgA antibodies to gluten or casein were found in 30% of children with autism while in schizophrenic patients 86% had elevated IgA antibodies to gluten and 67% to casein; some normal children and adults have these antibodies but only in trace amounts. When schizophrenic patients were treated with dialysis or a gluten-casein free diet, or both (Cade, R., Wagemaker, H., Privette, R.M., Fregly, M., Rogers, J. and Orlando, J. (1990) Psychiatry: A World Prespective 1: 494-500) peptiduria and Brief Psychiatric Rating Scores fell while abnormal behavior diminished. A gluten-casein free diet was accompanied by improvement in 81% of autistic children within 3 months in most of the behavior categories. Our data provide support for the proposal that many patients with schizophrenia or autism suffer due to absorption of exorphins formed in the intestine from incomplete digestion of gluten and casein.