背景:在人类炎症性肠病(IBD)中,营养吸收不良会导致脂溶性维生素缺乏,尤其是维生素D。在兽类中,维生素D浓度降低在患有慢性肠病(CE)的狗中相对常见,但是缺乏其他脂溶性维生素(FSVs)状态的数据。
目的:测定血清视黄醇,维生素D,和α-生育酚在狗与健康狗相比,并比较临床,CE和健康犬之间的临床病理变量,以检测与FSVs浓度降低的关联。
方法:18只客户拥有CE的狗和33只健康的狗。
方法:血清25-羟基维生素D(25[OH]D),比较各组血清视黄醇和α-生育酚浓度。相关性和多元回归模型用于检查血清25(OH)D,视黄醇,和α-生育酚浓度以及临床和临床病理变量。
结果:血清白蛋白浓度低的狗比血清白蛋白浓度正常的狗更可能有更低的25(OH)D浓度。患有CE的狗有较高的血清视黄醇浓度,和可变的α-生育酚浓度。这些维生素浓度失调的原因尚不清楚,需要进一步研究。
结论:应监测患有重度CE的狗的25(OH)D浓度降低。需要进一步的研究来评估这些患者补充维生素D的临床相关性和可能的益处。
BACKGROUND: In inflammatory bowel disease (IBD) of humans, nutrient malabsorption can result in fat-soluble vitamin deficiency, especially of vitamin D. In veterinary species, decreased concentrations of vitamin D are relatively common in dogs with chronic enteropathy (CE), but data on the status of other fat-soluble vitamins (FSVs) is lacking.
OBJECTIVE: Determine the serum concentrations of retinol, vitamin D, and α-tocopherol in dogs with CE compared with healthy dogs and compare clinical, clinicopathologic variables between CE and healthy dogs to detect associations with decreased FSVs concentrations.
METHODS: Eighteen client-owned dogs with CE and 33 healthy dogs.
METHODS: Serum 25-hydroxyvitamin D (25[OH]D), serum retinol and α-tocopherol concentrations were compared between groups. Correlations and multiple regression modeling were used to examine the relationship between serum 25(OH)D, retinol, and α-tocopherol concentrations and clinical and clinicopathological variables.
RESULTS: Dogs with low serum albumin concentrations were more likely to have lower 25(OH)D concentrations than dogs with normal serum albumin concentration. Dogs with CE had higher serum concentrations of retinol, and variable α-tocopherol concentrations. The cause of these dysregulated vitamin concentrations is unclear and requires further study.
CONCLUSIONS: Dogs with severe forms of CE should be monitored for decreased concentrations of 25(OH)D. Additional studies are needed to evaluate the clinical relevance and the possible benefit of vitamin D supplementation in these patients.