■喉在发声和气道保护中起着关键作用,喉癌通过各种症状表现出来。当代的策略集中在喉保存上,特别是通过利用放射治疗的非手术方式治疗。这项研究的目的是评估局部晚期喉鳞状细胞癌患者进行明确放射治疗后的喉保存率,并在现实世界中研究初次复发后的抢救治疗。
■分析包括在东京大学医院接受明确放射治疗的40例局部晚期喉鳞状细胞癌患者。治疗包括外部放射治疗(35个部分中70Gy)和选择性淋巴结照射。主要研究结果是生存评估,总生存率,本地控制,以及影响喉保存的因素。
■患者的中位年龄为64.5岁,其中80%是男性。对82.5%的患者进行了化疗。3年总生存率,无进展,喉保存存活率为86.3%,66.8%,78.4%,分别。单变量和多变量分析确定化疗与有利的喉部保存生存期显著相关(p<0.001)。
■对于局部晚期喉鳞状细胞癌,明确的放疗结果有利于喉部保留。这项研究强调了化疗在全面患者管理中的重要性。然而,更大的前瞻性研究对于验证和优化这种疾病的治疗方法至关重要.
UNASSIGNED: The larynx plays a pivotal role in vocalization and airway protection, and laryngeal cancer manifests through various symptoms. Contemporary strategies focus on laryngeal preservation, particularly through non-surgical modality therapies that utilize radiotherapy. The aim of this study was to assess the laryngeal preservation rate after definitive radiation therapy in patients with locally advanced laryngeal squamous cell carcinoma and investigate salvage therapy subsequent to the initial recurrence in a real-world context.
UNASSIGNED: Analysis included a total of 40 patients with locally advanced laryngeal squamous cell carcinoma who were treated with definitive radiotherapy in the University of Tokyo Hospital. Treatment involved external beam radiotherapy (70 Gy in 35 fractions) with elective nodal irradiation. The main study outcomes were assessment of survival, overall survival, local control, and the factors influencing laryngeal preservation.
UNASSIGNED: The patients exhibited a median age of 64.5 years, and 80% of them were men. Chemotherapy was administered to 82.5% of the patients. The 3-year overall survival, progression-free, and laryngeal preservation survival rates were 86.3%, 66.8%, and 78.4%, respectively. Univariate and multivariate analyses identified chemotherapy to be significantly associated with favorable laryngeal preservation survival (p<0.001).
UNASSIGNED: Definitive radiotherapy results in favorable outcomes for laryngeal preservation in locally advanced laryngeal squamous cell carcinoma. This study emphasizes the importance of chemotherapy in comprehensive patient management. Nevertheless, larger prospective studies are crucial to validate and optimize therapeutic approaches for this condition.