■我们调查了围产期心肌病(PPCM)的危险因素和特征性临床特征,为早期识别奠定了基础,筛选,诊断,并对高危孕妇进行干预。
■进行了一项回顾性病例对照研究,以分析来自中国人群的44例PPCM患者和226例正常孕妇的数据。
■在各种因素如年龄,体重指数(BMI),心率,和病史。Logistic回归模型识别异常心电图(OR=18.852),上呼吸道感染(OR=41.822),妊娠期高血压(OR=18.188),剖宫产(OR=8.394)为PPCM的危险因素。在PPCM患者中观察到的常见临床特征包括咳嗽,喘息,胸闷(68.18%),左心增大(56.82%)和瓣膜功能不全(81.82%)。此外,在一部分患者中检测到心病毒(43.18%),NT-proBNP升高≥400pg/mL(81.82%).
■在中国人口中,怀孕期间异常心电图的存在,上呼吸道感染史,妊娠期高血压,产妇选择剖宫产提示PPCM发展的可能性。高龄等因素,心血管疾病家族史,妊娠期糖尿病,子痫,贫血,应考虑低蛋白血症。临床上,出现咳嗽的患者,喘息,胸闷,左心增大,瓣膜功能不全和NT-proBNP升高≥400pg/mL。本研究可为医师早期识别和筛查PPCM患者提供有价值的参考。
UNASSIGNED: We investigated the risk factors and characteristic clinical features of peripartum cardiomyopathy (PPCM) to lay the groundwork for early identification, screening, diagnosis, and intervention in high-risk pregnant women.
UNASSIGNED: A retrospective case-control study was conducted to analyze data from 44 patients with PPCM and 226 normal pregnant women from a Chinese population.
UNASSIGNED: Significant differences were found between the groups in terms of various factors such as age, body mass index (BMI), heart rate, and medical history. Logistic regression models identified abnormal electrocardiography (OR=18.852), upper respiratory tract infection (OR=41.822), gestational hypertension (OR=18.188), and cesarean section (OR=8.394) as risk factors for PPCM. Common clinical features observed in patients with PPCM included cough, wheezing, and chest tightness (68.18%), left heart enlargement (56.82%) and valvular insufficiency (81.82%). Additionally, cardiotropic virus was detected in a subset of patients (43.18%) and NT-proBNP was elevated ≥ 400 pg/mL (81.82%).
UNASSIGNED: In the Chinese population, the presence of abnormal electrocardiograms during pregnancy, history of upper respiratory tract infection, gestational hypertension, and maternal choice of cesarean section suggest the possibility of PPCM development. Factors such as advanced age, family history of cardiovascular disease, gestational diabetes mellitus, eclampsia, anemia, and hypoproteinemia should be considered. Clinically, patients present with cough, wheezing, chest tightness, enlarged left heart, valvular insufficiency and NT-proBNP elevated ≥ 400 pg/mL. This study could serve as a valuable reference for medical practitioners for the early identification and screening of patients with PPCM.