PDF(Pubmed)
Abstract：
Preeclampsia and peripartum cardiomyopathy (PPCM) are significant obstetric problems that can arise during or after pregnancy. Both are known to be causes of maternal mortality and morbidity. Several recent studies have suggested a link between preeclampsia and the pathophysiology of PPCM. However, the common thread that connects the two has yet to be thoroughly and fully articulated. Here, we investigate the complex dynamics of preeclampsia and PPCM in this review. Our analysis focuses mainly on inflammatory and immunological responses, endothelial dysfunction as a shared pathway, and potential genetic predisposition to both diseases. To begin, we will look at how excessive inflammatory and immunological responses can lead to clinical symptoms of both illnesses, emphasizing the role of proinflammatory cytokines and immune cells in modifying vascular and tissue responses. Second, we consider endothelial dysfunction to be a crucial point at which endothelial damage and activation contribute to pathogenesis through increased vascular permeability, vascular dysfunction, and thrombus formation. Finally, we examine recent information suggesting genetic predispositions to preeclampsia and PPCM, such as genetic variants in genes involved in the management of blood pressure, the inflammatory response, and heart structural integrity. With this synergistic study, we seek to encourage more research and creative therapy solutions by emphasizing the need for an interdisciplinary approach to understanding and managing the connection between preeclampsia and PPCM.
摘要：
先兆子痫和围产期心肌病（PPCM）是怀孕期间或之后可能出现的重大产科问题。众所周知，两者都是孕产妇死亡和发病的原因。最近的几项研究表明先兆子痫与PPCM的病理生理学之间存在联系。然而,连接两者的共同螺纹尚未完全铰接。这里,本文综述了子痫前期和PPCM的复杂动态。我们的分析主要集中在炎症和免疫反应，内皮功能障碍作为共享途径，以及这两种疾病的潜在遗传易感性。开始,我们将研究过度的炎症和免疫反应如何导致这两种疾病的临床症状，强调促炎细胞因子和免疫细胞在改变血管和组织反应中的作用。第二,我们认为内皮功能障碍是内皮损伤和激活通过血管通透性增加促进发病的关键点。血管功能障碍,和血栓形成。最后,我们检查了最近的信息，表明先兆子痫和PPCM的遗传易感性，例如与血压管理有关的基因的遗传变异，炎症反应，和心脏结构的完整性。通过这项协同研究，我们强调需要采用跨学科的方法来理解和管理先兆子痫和PPCM之间的联系,从而鼓励更多的研究和创造性的治疗方案.
