免疫系统,充当身体的“国防军”,在监视中发挥作用,防御。免疫系统的任何破坏都可能导致免疫相关疾病的发展。广泛的研究表明间充质干细胞(MSCs)在这些疾病中至关重要的免疫调节作用。特别感兴趣的是在特定条件下诱导体细胞的能力,产生一种具有干细胞特征的新细胞类型,称为诱导多能干细胞(iPSC)。iPSCs向MSCs的分化,特异性诱导多能干细胞来源的间充质干细胞(iMSCs),作为解决MSC挑战的潜在解决方案,可能作为传统药物疗法的替代品。此外,iMSC的产品,称为诱导多能干细胞来源的间充质干细胞来源的细胞外囊泡(iMSC-EV),可能表现出类似于iMSC的功能。由于电动汽车的生物学优势,它们已成为“无细胞疗法”的焦点。这里,我们全面总结了iMSCs对免疫细胞的生物学影响,探讨了iMSC和iMSC-EV在疾病中的应用,并简要讨论了电动汽车的基本特征。最后,我们概述了目前与iMSC和iMSC-EV相关的优势和挑战.我们希望这篇与iMSCs和iMSC-EV相关的综述将有助于开发新的疾病治疗方法。
The immune system, functioning as the body\'s \"defense army\", plays a role in surveillance, defense. Any disruptions in immune system can lead to the development of immune-related diseases. Extensive researches have demonstrated the crucial immunoregulatory role of mesenchymal stem cells (MSCs) in these diseases. Of particular interest is the ability to induce somatic cells under specific conditions, generating a new cell type with stem cell characteristics known as induced pluripotent stem cell (iPSC). The differentiation of iPSCs into MSCs, specifically induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs), hold promise as a potential solution to the challenges of MSCs, potentially serving as an alternative to traditional drug therapies. Moreover, the products of iMSCs, termed induced pluripotent stem cell-derived mesenchymal stem cell-derived extracellular vesicles (iMSC-EVs), may exhibit functions similar to iMSCs. With the biological advantages of EVs, they have become the focus of \"cell-free therapy\". Here, we provided a comprehensive summary of the biological impact of iMSCs on immune cells, explored the applications of iMSCs and iMSC-EVs in diseases, and briefly discussed the fundamental characteristics of EVs. Finally, we overviewed the current advantages and challenges associated with iMSCs and iMSC-EVs. It is our hope that this review related to iMSCs and iMSC-EVs will contribute to the development of new approaches for the treatment of diseases.