■自身免疫性疾病与虚弱的因果关系尚未确定。我们进行了孟德尔随机化(MR)研究,以揭示自身免疫性疾病与虚弱之间的因果关系。
■进行了MR分析,以探索自身免疫性疾病与虚弱之间的关系,使用汇总的全基因组关联统计。
■通过全面细致的筛选过程,我们纳入了46、7、12、20、5和53个单核苷酸多态性(SNP)作为甲状腺功能减退症的工具变量(IVs),甲状腺功能亢进,类风湿性关节炎(RA),1型糖尿病(T1D),多发性硬化症(MS),和整体的自身免疫性疾病,分别。我们的分析显示甲状腺功能减退(OR=1.023,95%CI:1.008-1.038,p=0.0015),甲状腺功能亢进(OR=1.024,95%CI:1.004-1.045,p=0.0163),RA(OR=1.031,95%CI:1.011-1.052,p=0.0017),T1D(OR=1.011,95%CI:1.004-1.017,p=0.0012),和整体自身免疫性疾病(OR=1.044,95%CI:1.028-1.061,p=5.32*10^-8)对虚弱表现出积极的因果关系。相反,MS(OR=0.984,95%CI:0.977-0.992,p=4.87*10^-5)与虚弱之间可能存在负因果关系。CochranQ检验表明源自甲状腺功能减退症的IVs之间存在异质性,甲状腺功能亢进,T1D,和整体自身免疫性疾病。MR-Egger回归分析显示,在任何进行的分析中都没有水平多效性。
■这项研究阐明了甲状腺功能减退,甲状腺功能亢进,RA,T1D,总体自身免疫性疾病与虚弱风险升高有关.相反,MS似乎与虚弱风险的潜在降低有关。
UNASSIGNED: The causality of autoimmune diseases with frailty has not been firmly established. We conducted this Mendelian randomization (MR) study to unveil the causal associations between autoimmune diseases with frailty.
UNASSIGNED: A MR analyses were performed to explore the relationships between autoimmune disease and frailty, using summary genome-wide association statistics.
UNASSIGNED: Through a comprehensive and meticulous screening process, we incorporated 46, 7, 12, 20, 5, and 53 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for hypothyroidism, hyperthyroidism, rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), and overall autoimmune disease, respectively. Our analysis revealed that hypothyroidism (OR = 1.023, 95% CI: 1.008-1.038, p = 0.0015), hyperthyroidism (OR = 1.024, 95% CI: 1.004-1.045, p = 0.0163), RA (OR = 1.031, 95% CI: 1.011-1.052, p = 0.0017), T1D (OR = 1.011, 95% CI: 1.004-1.017, p = 0.0012), and overall autoimmune disease (OR = 1.044, 95% CI: 1.028-1.061, p = 5.32*10^-8) exhibited a positive causal effect on frailty. Conversely, there may be a negative causal association between MS (OR = 0.984, 95% CI: 0.977-0.992, p = 4.87*10^-5) and frailty. Cochran\'s Q test indicated heterogeneity among IVs derived from hypothyroidism, hyperthyroidism, T1D, and overall autoimmune diseases. The MR-Egger regression analyzes revealed an absence of horizontal pleiotropy in any of the conducted analyses.
UNASSIGNED: This study elucidates that hypothyroidism, hyperthyroidism, RA, T1D, and overall autoimmune disease were linked to an elevated risk of frailty. Conversely, MS appears to be associated with a potential decrease in the risk of frailty.