目的:饮酒是头颈癌(HNC)的主要危险因素,这种风险可能被乙醇脱氢酶(ADH)基因改变。为了更好地了解ADH3多态性在HNC患者中的作用,设计了更多的研究,并增加了试验序贯分析和功能分析。
方法:在多个数据库中进行了搜索,包括PubMed/Medline,WebofScience,Scopus,和Cochrane图书馆,截至2024年5月5日,没有任何限制来寻找相关研究。使用RevMan5.3软件计算效果大小。这些表示为比值比(OR),置信区间为95%。
结果:荟萃分析纳入了27篇文献。*1/*1、*1/*2和*2/*2基因型在HNC病例中的频率为47.14%,41.06%,和11.80%,分别,对照组为50.56%,38.29%,和11.15%,分别。等位基因模型的合并OR为1.11(p=0.18),对于纯合模型为0.95(p=0.64),对于杂合模型为0.99(p=0.90),对于主导模型为1.11(p=0.14),隐性模型为0.98(p=0.78)。在亚洲人中,这三个模型显示出显著的相关性.在癌症亚型亚组中,在咽癌亚型中发现了保护性的显著关联.
结论:目前的分析表明,ADH3多态性可能对HNC的风险没有显著影响,但是这种多态性在亚洲人中的风险增加,在咽癌中也有保护作用。
OBJECTIVE: Alcohol drinking is a major risk factor for head and neck cancer (HNC), and this risk may be modified by alcohol dehydrogenase (ADH) genes. The first systematic
review and meta-analysis was designed with more studies and added trial sequential analysis and functional analysis for a better understanding of the role of ADH3 polymorphism in HNC patients.
METHODS: A search was performed across several databases, including PubMed/Medline, Web of Science, Scopus, and Cochrane Library, up to May 5, 2024, without any restrictions to find pertinent studies. The RevMan 5.3 software was used to calculate the effect sizes. These were expressed as the odds ratio (OR) with a 95 % confidence interval.
RESULTS: Twenty-seven articles were included in the meta-analysis. The frequency of *1/*1, *1/*2, and *2/*2 genotypes in cases with HNC was 47.14 %, 41.06 %, and 11.80 %, respectively, and in controls was 50.56 %, 38.29 %, and 11.15 %, respectively. The pooled OR for the allelic model is 1.11 (p = 0.18), for the homozygous model is 0.95 (p = 0.64), for the heterozygous model is 0.99 (p = 0.90), for the dominant model is 1.11 (p = 0.14), and for the recessive model is 0.98 (p = 0.78). In the Asians, the three models showed an increased significant association. In the cancer subtype subgroup, a protective significant association was found in the pharyngeal cancer subtype.
CONCLUSIONS: The current analysis suggests that ADH3 polymorphism may not have a significant impact on the risk of HNC, but the polymorphism had an increased risk in Asians and a protective role in pharyngeal cancers.