■肠道菌群与慢性阻塞性肺疾病(COPD)的关系越来越受到学者们的关注和研究兴趣。然而,目前尚不清楚肠道菌群是COPD的致病因素,还是COPD的结果.因此,我们调查了COPD与肠道菌群之间的因果关系,旨在为临床诊断和治疗提供新的见解和参考。
■基于全基因组关联研究(GWAS)数据,我们采用了MR-Egger回归,随机效应逆方差加权(IVW)方法,双向孟德尔随机化(MR)分析的加权中位数方法。我们对异质性评估进行了Cochran的Q检验,并进行了多变量分析,敏感性分析,和异质性测试,以验证结果的可靠性和稳定性。
■利用MR分析,主要采用IVW方法,我们检测到一组11种肠道微生物与COPD相关.其中,细菌,家族XIII,梭菌感染组,Barnesiella,Collinsella,落叶松科NK4A136组,LachnospileaeUCG004,LachnosiliaceaeUCG010和拟杆菌被发现是COPD的保护因素。另一方面,Holdemanella和Marvinbryantia被确定为COPD的危险因素。holdemanella水平升高的个体表现出比健康者高1.141倍的发展为COPD的风险。那些具有增加的Martinbryantia水平的人具有1.154倍的风险。反向MR分析没有证据表明肠道微生物群与COPD发生之间存在因果关系。
■我们的研究建立了11种特定肠道微生物群与COPD之间的因果关系,为COPD的临床治疗提供新的见解和有价值的参考。然而,我们的结果主要基于数据库的分析,需要进一步的临床研究来阐明肠道菌群对COPD的影响及其具体的保护机制。
UNASSIGNED: The associations between gut microbiota and chronic obstructive pulmonary disease (COPD) have gained increasing attention and research interest among scholars. However, it remains unclear whether gut microbiota serves as a causal factor for COPD or if it is a consequence of the disease. Therefore, we investigated the causal relationship between COPD and gut microbiota, with intention of providing novel insights and references for clinical diagnosis and treatment.
UNASSIGNED: Based on the genome-wide association study (GWAS) data, we employed MR-Egger regression, random-effects inverse variance-weighted (IVW) method, and weighted median method for bidirectional Mendelian randomization (MR) analysis. We conducted Cochran\'s Q test for heterogeneity assessment and performed multivariable analysis, sensitivity analysis, and heterogeneity testing to validate the reliability and stability of results.
UNASSIGNED: Utilizing MR analysis, mainly employing the IVW method, we detected a collective of 11 gut microbiota species that exhibited associations with COPD. Among them, Bacteroidia, family XIII, Clostridium innocuum group, Barnesiella, Collinsella, Lachnospiraceae NK4A136 group, Lachnospiraceae UCG004, Lachnospiraceae UCG010, and Bacteroidales were found to be protective factors for COPD. On the other hand, Holdemanella and Marvinbryantia were identified as risk factors for COPD. Individuals with elevated levels of Holdemanella exhibited a 1.141-fold higher risk of developing COPD compared to their healthy counterparts, and those with increased levels of Marvinbryantia had a 1.154-fold higher risk. Reverse MR analysis yielded no evidence indicating a causal relationship between gut microbiota and COPD occurrence.
UNASSIGNED: Our study established a causal link between 11 specific gut microbiota species and COPD, offering novel insights and valuable references for targeted therapies in the clinical management of COPD. However, our results were mainly based on the analysis of database, and further clinical studies are needed to clarify the effects of gut microbiota on COPD and its specific protective mechanism.