背景:这项研究旨在探索大脑结构之间的关联,认知,轻度认知障碍(MCI)参与者的运动控制,专注于双重任务表现。
方法:纳入30例MCI患者和30例健康对照。使用蒙特利尔认知评估(MoCA)评估认知功能。使用基于体素的形态计量学(VBM)分析结构磁共振成像数据,以计算脑实质体积和灰质体积(GMV)。参与者进行了单任务和双任务定时向上(TUG)测试,分析了GMV差异与任务执行时间的相关性。
结果:MCI患者的MoCA评分明显降低,特别是在视觉空间/执行方面,注意,和延迟召回域(p<0.05)。MCI患者的双任务TUG执行时间显着增加(p<0.05)。小脑右前叶和两个胰岛的GMV与视觉空间/执行评分呈正相关(FDR校正,p<0.05)。MCI患者右侧小脑前叶和岛叶GMV显著降低(p<0.05)。右侧小脑前叶GMV与双任务执行时间呈负相关(r=-0.32,p=0.012)。
结论:小脑右前叶GMV较小与双重任务表现受损有关,这可能为MCI中认知和运动功能障碍的神经机制提供更多证据。
BACKGROUND: This study aimed to explore the associations between brain structures, cognition, and motor control in participants with mild cognitive impairment (MCI), with a focus on dual-task performance.
METHODS: Thirty MCI patients and thirty healthy controls were enrolled. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Structural magnetic resonance imaging data were analyzed using voxel-based morphometry (VBM) to calculate brain parenchyma volume and gray matter volume (GMV). Participants performed single- and dual-task Timed Up and Go (TUG) tests, and the correlations between significant GMV differences and task execution time was analyzed.
RESULTS: MCI patients showed significantly lower MoCA scores, particularly in visuospatial/executive, attention, and delayed recall domains (p < 0.05). Dual-task TUG execution time was significantly increased in MCI patients (p < 0.05). The GMV in the right anterior lobe of the
cerebellum and both insulae was positively correlated with visuospatial/executive scores (FDR-corrected, p < 0.05). The GMV of the right cerebellar anterior lobe and insula were significantly reduced in MCI patients (p < 0.05). The GMV of the right cerebellar anterior lobe was negatively correlated with dual-task execution time (r = -0.32, p = 0.012).
CONCLUSIONS: Smaller GMV in the right anterior lobe of the
cerebellum was associated with impaired dual-task performance, which may provide more evidence for the neural mechanisms of cognitive and motor function impairments in MCI.