目标:神经鞘瘤是一种罕见的间叶性肿瘤。在这项研究中,我们分析了99例神经鞘瘤的临床病理。这项回顾性研究深入研究了临床,病态,和腹部神经鞘瘤的免疫组织化学尺寸。
结果:一组99例,包括4个恶性和95个良性神经鞘瘤,经过精心检查。临床分析显示明显的性别分布(1:1.7,男女),平均年龄为58.5岁。大多数病例无症状。一组99例,包括4个恶性和95个良性神经鞘瘤,经过精心检查。临床分析显示明显的性别分布(1:1.7,男女),平均年龄为58.5岁。大多数病例无症状。肿瘤大小从0.5到30厘米,大多数良性病例在胃中有不同的位置,恶性肿瘤在腹部/小肠中有不同的位置。最初的误诊很常见。病理评估显示出明显的特征,包括安东尼A和B模式,梭形细胞,良性神经鞘瘤的淋巴鞘结构。恶性病例表现为非典型细胞,溃疡,和侵入性生长。免疫组织化学标记,如S100、SOX10和波形蛋白,通过有助于准确的诊断,始终证明阳性。治疗结果提示恶性病例预后不良,总生存期为10至41个月。相反,良性病例随访期间无复发或转移,尽管有非典型的行为。
结论:本研究强调了腹部神经鞘瘤的罕见性,并强调了对综合诊断形态学和免疫组织化学的需要。SOX10是准确诊断的关键和特异性标记。进一步的研究对于完善诊断方案和增强我们对腹部神经鞘瘤临床行为的理解至关重要。
OBJECTIVE: Schwannoma is a rare mesenchymal tumor. In this study, we analyzed clinicopathologically 99 schwannomas.This retrospective study delves into the clinical, pathological, and immunohistochemical dimensions of abdominal schwannomas.
RESULTS: A cohort of 99 cases, comprising 4 malignant and 95 benign schwannomas, was meticulously examined. Clinical analysis revealed a notable gender distribution (1:1.7, male to female) and an average age of 58.5 years. The majority of cases were asymptomatic. A cohort of 99 cases, comprising 4 malignant and 95 benign schwannomas, was meticulously examined. Clinical analysis revealed a notable gender distribution (1:1.7, male to female) and an average age of 58.5 years. The majority of cases were asymptomatic. Tumor sizes ranged from 0.5 to 30 cm, with distinct locations in the stomach for most benign cases and the abdomen/small intestine for malignancies. Initial misdiagnoses were frequent. Pathological evaluations revealed distinct features, including Antoni A and B patterns, spindle cells, and lymphatic sheath structures in benign schwannomas. Malignant cases exhibited atypical cells, ulcers, and invasive growth. Immunohistochemical markers, such as
S100, SOX10, and vimentin, consistently demonstrated positivity by contributing to accurate diagnoses. Treatment outcomes indicated a poor prognosis in malignant cases, with overall survival ranging from 10 to 41 months. Conversely, benign cases displayed no recurrence or metastasis during follow-up, despite atypical behaviors.
CONCLUSIONS: This study underscores the rarity of abdominal schwannomas and underscores the need for a comprehensive diagnostic morphology and immunohistochemistry. SOX10 emerges as a crucial and specific marker for accurate diagnosis. Further research is imperative to refine diagnostic protocols and enhance our understanding of the clinical behavior of abdominal schwannomas.