Abstract：
S100 proteins comprise a family of structurally related proteins that are calcium-sensitive. S100 proteins have been found to play various roles in regulation of cell apoptosis, cell proliferation and differentiation, cell migration and invasion, energy metabolism, calcium homeostasis, protein phosphorylation, anti-microbial activity and inflammation in a variety of cell types. While the specific function of many S100 proteins remains unknown, some of the S100 proteins serve as disease biomarkers as well as possible therapeutic targets in skin diseases. Interface dermatitis (ID) is a histopathological term that covers many different skin conditions including cutaneous lupus erythematosus, lichen planus, and dermatomyositis. These pathologies share similar histological features, which include basal cell vacuolization and lymphocytic infiltration at the dermal-epidermal junction. In this review, we summarize how the S100 protein family contributes to both homeostatic and inflammatory processes in the skin. We also highlight the role of S100 proteins in neuronal signalling, describing how this might contribute to neuroimmune interactions in ID and other skin pathologies. Last, we discuss what is known about the S100 family proteins as both biomarkers and potential treatment targets in specific pathologies.
摘要：
S100蛋白包含钙敏感的结构相关蛋白家族。已经发现S100蛋白在调节细胞凋亡中起着多种作用。细胞增殖和分化，细胞迁移和侵袭，能量代谢，钙稳态，蛋白质磷酸化，抗微生物活性和多种细胞类型的炎症。虽然许多S100蛋白的特定功能仍然未知，一些S100蛋白可作为皮肤疾病的生物标志物以及可能的治疗靶点。界面皮炎（ID）是一个组织病理学术语，涵盖了许多不同的皮肤病，包括皮肤红斑狼疮，扁平苔藓,和皮肌炎.这些病理具有相似的组织学特征，其中包括真皮-表皮交界处的基底细胞空泡化和淋巴细胞浸润。在这次审查中,我们总结了S100蛋白家族如何促进皮肤的稳态和炎症过程。我们还强调了S100蛋白在神经元信号中的作用，描述了这可能如何导致ID和其他皮肤病变中的神经免疫相互作用。最后,我们将讨论已知的S100家族蛋白作为特定病理中的生物标志物和潜在治疗靶标。
