PDF(Pubmed)
Abstract：
Schwannomas (SCHs) are benign neural tumors originating from Schwann cells of the peripheral nerve sheaths. These neoplasms typically exhibit hyalinized vessels with impaired vascular permeability; however, angioma-like features are rare. We report an intriguing case of a cutaneous SCH with unusual vascular changes in a 60-year-old female who presented with a tender nodular lesion on her lower back. Histopathological examination of the excised lesion revealed a schwannoma with a central area of thrombosis and a vascular proliferative lesion consistent with Masson\'s hemangioma (MH). MH, also known as intravascular papillary endothelial hyperplasia (IPEH), is a rare benign vascular lesion characterized by papillary endothelial hyperplasia and obliterative changes within vascular lumens. Immunohistochemical staining confirmed S100 positivity in the SCH component and highlighted the papillary endothelial lining by ERG (erythroblast transformation-specific regulated gene 1). To our knowledge, this is the first report of a schwannoma harboring MH. This unique case underscores the potential for rare vascular proliferation to arise within otherwise typical SCHs.
摘要：
神经鞘瘤（SCHs）是起源于周围神经鞘的施万细胞的良性神经肿瘤。这些肿瘤通常表现为玻璃样化血管，血管通透性受损；然而，血管瘤样特征很少见。我们报道了一个有趣的皮肤SCH病例，该病例在一名60岁的女性中出现了异常的血管变化，该女性的下背部有结节状病变。切除病变的组织病理学检查显示神经鞘瘤具有血栓形成的中央区域和与Masson血管瘤（MH）一致的血管增生性病变。MH,也称为血管内乳头状内皮增生（IPEH），是一种罕见的良性血管病变，其特征是乳头状内皮增生和血管腔内的闭塞性变化。免疫组织化学染色证实了S100在SCH成分中的阳性，并通过ERG（成红细胞转化特异性调节基因1）突出了乳头状内皮衬里。据我们所知,这是首次报告有MH的神经鞘瘤.这种独特的情况强调了在其他典型的SCH中出现罕见血管增殖的可能性。
