β-酪蛋白,牛奶中的一种主要蛋白质,分为A1和A2型变体。A1β-酪蛋白的消化产生肽β-casomorphin-7,其可引起胃肠(GI)不适,但是仅含有A2β-酪蛋白的A2奶可能比A1/A2(普通)奶更有益。这项研究的目的是评估摄入A2牛奶和A1/A2牛奶后胃肠道不适的差异。一个随机的,双盲,交叉人体试验对40名在食用牛奶后出现胃肠道不适的受试者进行.对于每个干预期,在2周的冲洗期后,首先食用A2牛奶(A2→A1/A2)或首先食用A1/A2牛奶2周(A1/A2→A2)。胃肠道症状评定量表(GSRS)评分,消化症状问卷,和实验室测试,包括粪便钙卫蛋白进行了评估。对于症状分析,采用广义估计方程伽马模型。与GSRS中的A1/A2牛奶相比,A2牛奶增加了腹胀(P=0.041)和稀便(P=0.026)。然而,A2牛奶引起的腹痛较少(P=0.050),与消化症状问卷中的A1/A2牛奶相比,粪便紧迫性(P<0.001)和borbygmus(P=0.007)。此外,与A1/A2牛奶相比,食用A2牛奶后粪便钙卫蛋白也减少或减少(P=0.030),这种变化在男性中(P=0.005)比女性更为明显。试验期间无明显不良反应。A2牛奶缓解了A2牛奶消费后韩国人的消化不适(ClinicalTrials.govNCT06252636和CRISKCT0009301)。
β-Casein, a major protein in cow\'s
milk, is divided into the A1 and A2 type variants. Digestion of A1 β-casein yields the peptide β-casomorphin-7 which could cause gastrointestinal (GI) discomfort but A2 milk containing only A2 β-casein might be more beneficial than A1/A2 (regular) milk. The aim of this study was to evaluate the differences in GI discomfort after ingestion of A2 milk and A1/A2
milk. A randomized, double-blind, cross-over human trial was performed with 40 subjects who experienced GI discomfort following milk consumption. For each intervention period, either A2
milk first (A2→A1/A2) or A1/A2
milk was first consumed for 2 weeks (A1/A2→A2) following a 2-week washout period. GI symptom rating scale (GSRS) scores, questionnaire for digestive symptoms, and laboratory tests including fecal calprotectin were evaluated. For symptom analysis, generalized estimating equations gamma model was used. A2
milk increased bloating (P = 0.041) and loose stools (P = 0.026) compared to A1/A2
milk in GSRS. However, A2 milk caused less abdominal pain (P = 0.050), fecal urgency (P < 0.001) and borborygmus (P = 0.007) compared to A1/A2 milk in questionnaire for digestive symptoms. In addition, fecal calprotectin also decreased or less increased after consumption of A2 milk compared to A1/A2 milk (P = 0.030), and this change was more pronounced in males (P = 0.005) than in females. There were no significant adverse reactions during the trial. A2
milk alleviated digestive discomfort in Koreans following A2
milk consumption (ClinicalTrials.gov NCT06252636 and CRIS KCT0009301).