对提高生活质量和延长寿命的全球需求推动了组织工程和再生医学的重大进步。这些领域利用一系列跨学科的理论和技术来修复结构受损或受损的组织和器官,以及恢复正常功能。然而,药物的临床疗效,材料,在实验室水平使用的强效细胞总是受到技术限制的限制。已经开发了一种称为适应性微针的新型平台来解决上述问题。这些微针为各种货物的局部分布提供了解决方案,同时使侵入性最小化。微针由于其有效的施用和提供无痛和方便的过程的能力而在临床环境中提供了良好的患者依从性。在这篇评论文章中,我们总结了微针的最新发展,我们开始对各种微针系统进行分类,优势,和基本属性。随后,它提供了不同类型的微针的全面概述,用于制造微针的材料,理想微针的基本特性,以及它们在组织工程和再生医学中的应用,主要专注于保存和恢复受损的组织和器官。通过总结其在组织工程和再生医学中的未来治疗应用,已经讨论了局限性和观点。
The global demand for an enhanced quality of life and extended lifespan has driven significant advancements in tissue engineering and regenerative medicine. These fields utilize a range of interdisciplinary theories and techniques to repair structurally impaired or damaged tissues and organs, as well as restore their normal functions. Nevertheless, the clinical efficacy of medications, materials, and potent cells used at the laboratory level is always constrained by technological limitations. A novel platform known as adaptable
microneedles has been developed to address the abovementioned issues. These
microneedles offer a solution for the localized distribution of various cargos while minimizing invasiveness. Microneedles provide favorable patient compliance in clinical settings due to their effective administration and ability to provide a painless and convenient process. In this review article, we summarized the most recent development of
microneedles, and we started by classifying various microneedle systems, advantages, and fundamental properties. Subsequently, it provides a comprehensive overview of different types of
microneedles, the material used to fabricate
microneedles, the fundamental properties of ideal
microneedles, and their applications in tissue engineering and regenerative medicine, primarily focusing on preserving and restoring impaired tissues and organs. The limitations and perspectives have been discussed by concluding their future therapeutic applications in tissue engineering and regenerative medicines.