背景:毛发角化病(KP)是一种常见的良性皮肤病,其特征是毛囊处的小肿块以及周围的发红,显着影响美学和心理健康。
目的:本研究调查了非交联透明质酸(HA)化合物治疗KP的潜在益处。
方法:分裂体,调查员失明,随机化,进行了个体内比较临床试验.将非交联的HA化合物注射到两个上臂上的受KP影响的区域中。治疗以4周的间隔进行四个疗程。失明的医生和患者评估红斑的差异,皮肤粗糙度,以及最终随访时治疗区和控制区之间的总体评分。治疗后第12周和第24周,采用四点量表评估受试者感知的治疗效果。此外,皮肤镜图像,组织学改变,并监测不良事件.
结果:医师评估显示,与对照组相比,治疗区域的粗糙度和总体评分显著降低。患者自我评估也反映了粗糙度的改善,发红,以及在最后一次访问中接受治疗的双方的总体得分,35.71%的患者在治疗后第24周表现出红肿持续改善,71.43%的患者报告粗糙度持续改善。皮肤镜检查显示,治疗组受试者的滤泡塞数量和红斑程度均显着增加。组织病理学结果也显示出改善。
结论:这项研究表明,在KP治疗中,非交联HA化合物可有效改善皮肤粗糙度并促进毛干生长,显示良好的安全性。这些发现将其定位为临床实践中潜在可行的替代疗法。
BACKGROUND: Keratosis pilaris (KP) is a prevalent benign dermatological condition characterized by small bumps at the hair follicles alongside surrounding redness, significantly impacting both aesthetics and mental well-being.
OBJECTIVE: This study investigated the potential benefits of a non-cross-linked hyaluronic acid (HA) compound for treating KP.
METHODS: A split-body, investigator-blinded, randomized, intraindividual comparative clinical trial was conducted. The non-cross-linked HA compound was injected into KP-affected regions on both upper arms. The treatment was delivered across four sessions scheduled at 4-week intervals. Blinded physicians and patients assessed differences in erythema, skin roughness, and overall scores between treated and control areas at the final follow-up visit. At the 12th and 24th weeks post-treatment, a four-point scale was utilized to assess subjects\' perceived treatment efficacy. Additionally, dermoscopic images, histological alterations, and adverse events were monitored.
RESULTS: Physician assessments revealed a significant reduction in roughness and overall scores for treated areas compared to controls. Patient self-assessments also reflected improvements in roughness, redness, and overall scores for treated sides at the final visit, with 35.71% of patients demonstrating sustained improvement in redness and 71.43% reporting persistent improvements in roughness at 24th weeks post-treatment. The dermatoscopic examinations revealed a notable enhancement in both the quantity of follicular plugs and the extent of erythema among the subjects in the treatment group. Histopathological outcomes also demonstrated improvement.
CONCLUSIONS: This study suggests that the non-cross-linked HA compound effectively improves skin roughness and promotes hair shaft growth in KP treatment, demonstrating a favorable safety profile. These findings position it as a potentially viable alternative therapy in clinical practice.