目的:探讨抗苗勒管激素(AMH)和抑制素B(InhB)对中国达斡尔族更年期女性骨质疏松的诊断价值。
方法:选择绝经妇女175例,分为骨质疏松组(N=90)和对照组(N=85)。采用双能X线吸收法测量骨密度,和骨质疏松症的实验室指标,例如,血清骨钙蛋白(OC),β-胶原特殊序列(β-CTX),和I型前胶原氨基末端前肽(PINP),骨碱性磷酸酶(BALP),AMH,和InhB通过商业试剂盒测量。分析骨质疏松与AMH或InhB的关系。通过ROC曲线和logistic回归反映AMH和InhB的预测价值。
结果:BMD水平降低,OC水平降低,β-CTX,PINP,绝经后骨质疏松组BALP升高。更年期骨质疏松组的AMH和InhB浓度降低,且两者有联系。AMH和InhB可作为绝经妇女骨质疏松发生的独立指标,两者联合应用具有较高的诊断价值。
结论:绝经期妇女AMH和InhB测定对骨质疏松的检测有一定的临床意义。骨质疏松的发生与骨密度有关,OC,β-CTX,BALP,AMH,和InhB.
OBJECTIVE: To investigate the diagnostic value of anti-Mullerian hormone (AMH) and Inhibin B (InhB) in menopausal women with osteoporosis from the Chinese Daur ethnic group.
METHODS: A total of 175 menopausal women were selected and divided into the osteoporosis group (N = 90) and the control group (N = 85). BMD was measured by dual-energy X-ray absorptiometry, and laboratory indicators of osteoporosis, for example, serum osteocalcin (OC), β-collagen special sequence (β-CTX), and procollagen type I amino-terminal propeptide (PINP), bone alkaline phosphatase (BALP), AMH, and InhB were measured by commercial kits. The relationship between osteoporosis and AMH or InhB was analyzed. The predictive values of AMH and InhB were reflected by the ROC curve and logistic regression.
RESULTS: The level of BMD was decreased and the levels of OC, β-CTX, PINP, and BALP of the menopausal osteoporosis group were increased. The concentration of AMH and InhB in the menopausal osteoporosis group was decreased and they had connections with each other. AMH and InhB could be used as independent indicators for the occurrence of osteoporosis in menopausal women and their combination had a higher diagnostic value.
CONCLUSIONS: AMH and InhB measurements in menopausal women had a certain clinical significance in the detection of osteoporosis. The occurrence of osteoporosis was related to BMD, OC, β-CTX, BALP, AMH, and InhB.