■2019年冠状病毒病(COVID-19)的出现提出了一个重大而紧迫的全球公共卫生问题。在COVID-19感染的情况下,生物标志物有可能用于鉴定内皮和/或肺泡上皮损伤。
■评估使用聚合酶链反应(PCR)检测COVID-19感染呈阳性的住院患者的细胞间粘附分子-1(ICAM-1)和血管细胞粘附分子(VCAM-1)生物标志物的水平与病毒特异性免疫球蛋白;IgM,和IgG测试。这有助于改善临床管理和治疗方案。
一项病例对照研究,涉及90名COVID-19检测呈阳性的住院患者和40名明显健康的对照组患者,两组受试者均接受鼻咽拭子进行PCR和血液样本收集以评估血清;IgM,IgG,ICAM-1和VCAM-1水平。
■男性占患者的绝大多数(78.9%),只有一小部分女性(21.1%)P值0.1641。此外,这项研究中的每位患者至少有一个COVID-19的危险因素.研究者的结果显示,COVID-19患者的内皮细胞粘附指标(ICAM-1和VCAM-1)含量较高,平均值分别为126.27±89.51ng/mL和109.74±96.57ng/mL。同时,对照组中ICAM-1和VCAM-1均处于正常水平,与患者组相比,P值分别为0.0028和0.0032。
■粘附标记ICAM和VCAM在COVID-19的发展中起着至关重要的作用,并且与急性和持续免疫反应相关的强内皮激活和功能障碍通过在COVID-19患者中发现IgM和IgG抗体的存在与较高水平的ICAM-1和VCAM-1之间的实质性相关性。
UNASSIGNED: The advent of the Coronavirus Disease 2019 (COVID-19) has presented a substantial and urgent global public health issue. Biomarkers have the potential to be utilized for the identification of endothelium and/or alveolar epithelial damage in instances of COVID-19 infection.
UNASSIGNED: to evaluate the levels of Intercellular adhesion molecule-1 (ICAM-1) and Vascular cell adhesion molecule (VCAM-1) biomarkers in hospitalized patients who tested positive for COVID-19 infection using Polymerase Chain Reaction (PCR) with the virus specific Immunoglobulins; IgM, and IgG testing. This can help with improved clinical management and treatment programs.
UNASSIGNED: A case-control study that involved 90 hospitalized patients who tested positive for COVID-19 and 40 apparently healthy control patients, subjects in both groups underwent nasopharyngeal swabs for PCR and blood sample collection for evaluation of serum; IgM, IgG, ICAM-1 and VCAM-1 levels.
UNASSIGNED: Males made up the vast majority of the patients (78.9%), with only a minor percentage of females (21.1%) P value 0.1641. Furthermore, every patient in this study had a minimum of one risk factor for COVID-19. The investigator\'s results show that COVID-19 patients had higher amounts of endothelial cell adhesion indicators (ICAM-1 and VCAM-1) with mean values of 126.27 ± 89.51 ng/mL and 109.74 ± 96.57 ng/mL respectively. While, ICAM-1 and VCAM-1, were present at normal levels in the control group with difference P value 0.0028 and 0.0032 in comparison to the patient\'s group respectively.
UNASSIGNED: The adhesive markers ICAM and VCAM play a crucial role in the development of COVID-19 and the strong endothelial activation and dysfunction linked to both acute and persistent immunological responses is shown by the substantial correlation found in COVID-19 patients between the presence of IgM and IgG antibodies and higher levels of ICAM-1 and VCAM-1.