PDF(Pubmed)
Abstract：
Hepatocellular carcinoma (HCC) is a highly lethal cancer with a growing global incidence and is often associated with poor prognosis due to its tendency to metastasize. Intercellular adhesion molecule (ICAM) 1 is a transmembrane protein found in various cancer cells and is associated with the spread of cancer and poor prognosis. Chemokine (C-X-C motif) ligand 1 (CXCL1) is a chemokine that significantly affects the cell motility of various cancers. However, the role of CXCL1 in ICAM-1 expression and in metastasis of hepatocellular carcinoma remains unclear. We determined that CXCL1 expression is positively and significantly associated with advanced-stage tumors in the HCC tissue array. Kaplan-Meier analysis revealed worse overall survival rates in the high CXCL1 expression group, suggesting its potential as a biomarker for cancer progression and stimulating hepatocellular carcinoma cells with CXCL1 enhanced migration abilities by upregulating ICAM-1 expression. CXCL1 was shown to enhance ICAM-1-dependent cell motility by inhibiting miR-30b-5p. This study provides novel evidence that CXCL1 could serve as a therapeutic target for metastasis in hepatocellular carcinoma.
摘要：
肝细胞癌（HCC）是一种高致命性癌症，全球发病率不断增长，并且由于其转移趋势，通常与预后不良有关。细胞间粘附分子(ICAM)1是在各种癌细胞中发现的跨膜蛋白,并且与癌症的扩散和不良预后相关。趋化因子(C-X-C基序)配体1(CXCL1)是显著影响各种癌症的细胞运动性的趋化因子。然而,CXCL1在肝细胞癌ICAM-1表达和转移中的作用尚不清楚.我们确定CXCL1表达与HCC组织阵列中的晚期肿瘤呈正相关且显着相关。Kaplan-Meier分析显示，CXCL1高表达组的总生存率较差，提示其作为癌症进展的生物标志物和刺激具有CXCL1的肝细胞癌细胞的潜力通过上调ICAM-1表达来增强迁移能力。CXCL1显示通过抑制miR-30b-5p增强ICAM-1依赖性细胞运动。这项研究提供了新的证据，表明CXCL1可以作为肝细胞癌转移的治疗靶标。
