目的:美国陆军基本战斗训练(BCT)在大多数情况下改善了胫骨体积骨矿物质密度(BMD)和结构,但不是所有的士兵。很少有研究调查BCT期间血清骨生物标志物的变化是否与BCT后胫骨BMD和骨结构的变化有关。
目的:表征BCT过程中骨生物标志物的变化,并研究骨生物标志物的变化与胫骨BMD和骨结构变化之间的关系。
方法:在这项为期10周的前瞻性观察研究中,我们招募了235名进入BCT的学员。学员在整个BCT中每周提供禁食的血液样本和问卷。在BCT期间,每两周通过酶联免疫吸附测定法测量1型胶原蛋白的N端前肽(PINP)和1型胶原蛋白的C端端肽(CTX)。我们通过双能X线骨密度仪和骨骼结构评估身体成分和质量,微体系结构,通过基线和BCT后的高分辨率外周定量计算机断层扫描,胫骨远端的矿物质密度。
结果:男性(n=110)和女性(n=125)均为年轻(20.9±3.7和20.7±4.3岁,分别),正常至超重BMI(分别为25.2±4.1和24.2±3.6kg/m2)。在女学员中,与基线相比,BCT期间和之后的PINP增加,在第4周,PINP增加最大(45.4%±49.6,p<0.0001),而CTX没有变化。男性学员的PINP也有所增加,但仅在第2周和第4周(分别为21.9%±24.5,p=0.0027和35.9%±35.8,p<0.0001)。与女学员不同,在男性中,CTX在第4周低于基线,八,和BCT后。从基线到第4周BCT的PINP变化与胫骨BMD的变化呈正相关,TB。BMD,TB。Th,TB。BV/TV,CTTh,CTAr,还有CT。从基线到BCT后的Po。
结论:在美国陆军BCT期间,骨形成标志物PINP增加,尤其是前四周.PINP增加,但不是CTX,与胫骨远端BMD和骨结构改善有关。
OBJECTIVE: U.S. Army Basic Combat Training (BCT) improves tibial volumetric bone mineral density (BMD) and structure in most, but not all soldiers. Few studies have investigated whether changes in serum bone biomarkers during BCT are associated with changes in tibial BMD and bone structure following BCT.
OBJECTIVE: To characterize bone biomarker changes during BCT and to investigate the relationship between changes in bone biomarkers and changes in tibial BMD and bone structure.
METHODS: We enrolled 235 trainees entering BCT in this ten-week prospective observational study. Trainees provided fasted blood samples and questionnaires weekly throughout BCT. Procollagen type 1 N-terminal propeptide (PINP) and C-terminal telopeptide of type 1 collagen (CTX) were measured by enzyme-linked immunoabsorbent assays every two weeks during BCT. We evaluated body composition and mass via dual-energy X-ray absorptiometry and bone structure, microarchitecture, and mineral density at the distal tibia via high-resolution peripheral quantitative computed tomography at baseline and post-BCT.
RESULTS: Both male (n = 110) and female trainees (n = 125) were young (20.9 ± 3.7 and 20.7 ± 4.3 years, respectively), with normal to overweight BMIs (25.2 ± 4.1 and 24.2 ± 3.6 kg/m2, respectively). In female trainees, PINP increased during and post-BCT compared to baseline, with the greatest increase in PINP at week four (45.4 % ± 49.6, p < 0.0001), whereas there were no changes in CTX. PINP also increased in male trainees, but only at weeks two and four (21.9 % ± 24.5, p = 0.0027 and 35.9 % ± 35.8, p < 0.0001, respectively). Unlike female trainees, in males, CTX was lower than baseline at weeks four, eight, and post-BCT. The change in PINP from baseline to week four of BCT was positively associated with changes in tibial BMD, Tb.BMD, Tb.Th, Tb.BV/TV, Ct.Th, Ct.Ar, and Ct.Po from the baseline to post-BCT.
CONCLUSIONS: The bone formation marker PINP increases during U.S. Army BCT, especially during the first four weeks. Increases in PINP, but not CTX, were correlated with improved BMD and bone structure in the distal tibia.