PDF(Pubmed)
Abstract：
UNASSIGNED: Prolonged phenytoin (PHD) therapy in epileptics predisposes patients to deleterious effects on bone health causing osteoporosis; however, despite its known effect on wound healing, collagen and fibroblast proliferation, and osteogenic differentiation, its impact on fracture healing remains poorly researched, we, report two cases of early exuberant callus formation in long bone fractures in patients undergoing long-term PHD therapy.
UNASSIGNED: Two female patients with known seizure disorder on long-term PHD therapy experienced proximal humerus fractures after trivial trauma. Metabolic work-up revealed low serum calcium and Vitamin D3 levels with elevated ALP, serum osteocalcin, and iPTH. Despite planned surgery, both patients showed early exuberant callus formation post-trauma, leading to conservative management with successful outcomes.
UNASSIGNED: Regular bone health monitoring is crucial for patients on long-term antiepileptic therapy, especially PHD users, to enhance treatment outcomes and address potential complications. Although the influence of PHD on fracture healing is uncertain, the cases presented hint at a potential beneficial correlation, indicating a need for more research in this domain.
UNASSIGNED: Two female patients with known seizure disorder on long-term PHD therapy experienced proximal humerus fractures after trivial trauma. Metabolic work-up revealed low serum calcium and Vitamin D3 levels with elevated ALP, serum osteocalcin, and iPTH. Despite planned surgery, both patients showed early exuberant callus formation post-trauma, leading to conservative management with successful outcomes.
UNASSIGNED: Regular bone health monitoring is crucial for patients on long-term antiepileptic therapy, especially PHD users, to enhance treatment outcomes and address potential complications. Although the influence of PHD on fracture healing is uncertain, the cases presented hint at a potential beneficial correlation, indicating a need for more research in this domain.
摘要：
■癫痫患者长期使用苯妥英（PHD）治疗会使患者对骨骼健康产生有害影响，从而导致骨质疏松症；然而，尽管它对伤口愈合有已知的作用，胶原蛋白和成纤维细胞增殖，和成骨分化，它对骨折愈合的影响研究甚少，我们,报告2例长期接受PHD治疗的长骨骨折患者早期旺盛骨痂形成。
■两名长期接受PHD治疗的已知癫痫患者在轻微创伤后发生肱骨近端骨折。代谢检查显示血清钙和维生素D3水平低，ALP升高，血清骨钙蛋白，和iPTH。尽管计划好手术,两名患者在创伤后都表现出早期旺盛的愈伤组织形成，导致保守的管理和成功的结果。
■定期骨骼健康监测对于长期抗癫痫治疗的患者至关重要，尤其是博士用户，以提高治疗结果和解决潜在的并发症。虽然PHD对骨折愈合的影响尚不确定,所呈现的案例暗示了潜在的有益相关性，这表明需要在这一领域进行更多的研究。
■两名长期接受PHD治疗的已知癫痫患者在轻微创伤后发生肱骨近端骨折。代谢检查显示血清钙和维生素D3水平低，ALP升高，血清骨钙蛋白，和iPTH。尽管计划好手术,两名患者在创伤后都表现出早期旺盛的愈伤组织形成，导致保守的管理和成功的结果。
■定期骨骼健康监测对于长期抗癫痫治疗的患者至关重要，尤其是博士用户，以提高治疗结果和解决潜在的并发症。虽然PHD对骨折愈合的影响尚不确定,所呈现的案例暗示了潜在的有益相关性，这表明需要在这一领域进行更多的研究。
