UNASSIGNED: Two female patients with known seizure disorder on long-term PHD therapy experienced proximal humerus fractures after trivial trauma. Metabolic work-up revealed low serum calcium and Vitamin D3 levels with elevated ALP, serum osteocalcin, and iPTH. Despite planned surgery, both patients showed early exuberant callus formation post-trauma, leading to conservative management with successful outcomes.
UNASSIGNED: Regular bone health monitoring is crucial for patients on long-term antiepileptic therapy, especially PHD users, to enhance treatment outcomes and address potential complications. Although the influence of PHD on fracture healing is uncertain, the cases presented hint at a potential beneficial correlation, indicating a need for more research in this domain.
■两名长期接受PHD治疗的已知癫痫患者在轻微创伤后发生肱骨近端骨折。代谢检查显示血清钙和维生素D3水平低,ALP升高,血清骨钙蛋白,和iPTH。尽管计划好手术,两名患者在创伤后都表现出早期旺盛的愈伤组织形成,导致保守的管理和成功的结果。
■定期骨骼健康监测对于长期抗癫痫治疗的患者至关重要,尤其是博士用户,以提高治疗结果和解决潜在的并发症。虽然PHD对骨折愈合的影响尚不确定,所呈现的案例暗示了潜在的有益相关性,这表明需要在这一领域进行更多的研究。