PDF(Pubmed)
Abstract：
Background In the contemporary era, where science and technology know no boundaries, this in vivo study explores the impact of growth modulation therapy using Twin Block, Forsus Fatigue Resistant, and Clear Block appliances on alkaline phosphatase (ALP) levels in gingival crevicular fluid (GCF). Bone physiology involves modeling and remodeling, with orthodontics applying forces to teeth, influencing tissue reactivity and bone modeling. ALP, a marker of osteoblast function, plays a crucial role in bone growth. GCF reflects immunological and inflammatory responses during orthodontic force application, making it a valuable medium for studying ongoing metabolic processes related to bone turnover. Aim The study aims to comparatively analyze ALP levels in GCF during growth modulation therapy, assessing the efficacy of Twin Block, Forsus Fatigue Resistant, and Clear Block appliances. The research involves 30 experimental samples divided into three study groups and a control group. The samples are collected at various time intervals, and ALP levels are analyzed using a spectrophotometer. Statistical analysis includes paired and unpaired t-tests, one-way analysis of variance (ANOVA), and multiple comparisons. Results Results demonstrate a significant increase in ALP levels during the growth modulation therapy, indicating a positive correlation with bone remodeling. Twin Block appears to be the most effective appliance, exhibiting higher ALP activity compared to Clear Block and Forsus groups. Conclusion In conclusion, this study provides valuable insights into the biochemical responses during growth modulation therapy, emphasizing the potential of GCF analysis in understanding orthodontic treatment effects.
摘要：
背景在当代,在科学和技术没有界限的地方，这项体内研究探讨了使用TwinBlock的生长调节疗法的影响，Forsus抗疲劳,和ClearBlock矫治器对牙龈沟液（GCF）中碱性磷酸酶（ALP）水平的影响。骨生理学涉及建模和重塑，正畸对牙齿施加力，影响组织反应性和骨建模。ALP,成骨细胞功能的标志,在骨骼生长中起着至关重要的作用。GCF反映了正畸力施加过程中的免疫和炎症反应，使其成为研究与骨转换相关的正在进行的代谢过程的有价值的培养基。目的本研究旨在比较分析生长调节治疗期间GCF中的ALP水平，评估双块的疗效，Forsus抗疲劳,和清除块电器。该研究涉及30个实验样本，分为三个研究组和一个对照组。样本以不同的时间间隔收集，和ALP水平使用分光光度计分析。统计分析包括配对和非配对t检验，单向方差分析(ANOVA)，和多重比较。结果结果表明，生长调节治疗期间ALP水平显着增加，表明与骨重建呈正相关。TwinBlock似乎是最有效的设备，与ClearBlock和Forsus组相比，表现出更高的ALP活性。结论总之,这项研究为生长调节治疗期间的生化反应提供了有价值的见解，强调GCF分析在了解正畸治疗效果方面的潜力。
