背景:最近的研究表明习惯性饮用咖啡和绿茶对骨骼肌健康的潜在益处。然而,目前尚不清楚这些益处是否被遗传因素改变,特别是α-肌动蛋白-3(ACTN3)基因型,这与骨骼肌表型有关。这项研究旨在调查习惯性咖啡或绿茶消费与ACTN3基因型之间与骨骼肌质量(SMM)和强度相关的相互作用。
方法:这项横断面研究是对1,023名日本中老年人(619名女性,45-74岁)生活在社区中。使用生物电阻抗谱装置测量SMM,和握力(HGS)用于测量肌肉力量。ACTN3基因型(RR,RX,和XX)从血液样本中确定。使用性别特异性线性回归模型来分析咖啡或绿茶消费与ACTN3基因型之间与SMM和HGS相关的相互作用。
结果:在女性中,绿茶消费与ACTN3基因型与HGS之间存在显著的交互作用(P交互作用<0.05)。此外,分层分析显示绿茶消费量与HGS呈正相关,特别是在女性ACTN3XX基因型(P趋势<0.05)。在男性中,咖啡或绿茶消费与ACTN3基因型与SMM或HGS之间未观察到显着的相互作用(P相互作用>0.05)。
结论:我们的研究结果表明,与习惯性绿茶消费相关的骨骼肌力量益处可能取决于性别和ACTN3基因型。
BACKGROUND: Recent studies have suggested the potential benefits of habitual coffee and green tea consumption on skeletal muscle health. However, it remains unclear whether these benefits are modified by genetic factors, particularly the alpha-
actinin-3 (ACTN3) genotype, which is associated with the skeletal muscle phenotype. This study aimed to investigate the interaction between habitual coffee or green tea consumption and the ACTN3 genotype in association with skeletal muscle mass (SMM) and strength.
METHODS: This cross-sectional study was conducted on 1,023 Japanese middle-aged and older adults (619 females, aged 45-74 years) living in the community. SMM was gauged using a bioelectrical impedance spectroscopy device, and handgrip strength (HGS) was used to measure muscle strength. The ACTN3 genotype (RR, RX, and XX) was determined from blood samples. Sex-specific linear regression models were used to analyze the interactions between coffee or green tea consumption and the ACTN3 genotype in association with SMM and HGS.
RESULTS: In females, a significant interaction was observed between green tea consumption and the ACTN3 genotype in association with HGS (P interaction < 0.05). Furthermore, stratified analysis revealed a positive association between green tea consumption and HGS, specifically in females with the ACTN3 XX genotype (P trend < 0.05). In males, no significant interactions were observed between coffee or green tea consumption and the ACTN3 genotype in association with SMM or HGS (P interaction > 0.05).
CONCLUSIONS: Our findings suggest that the skeletal muscle strength benefits associated with habitual green tea consumption may be contingent upon sex and the ACTN3 genotype.