背景:在寻找特应性皮炎(AD)安全有效的治疗方法的不断努力中,饮食调整仍然相当关注。然而,研究的可获得性有限和学术文献中相互矛盾的发现构成了建立结论性建议的障碍。
方法:将孟德尔随机化(MR)应用于有关茶摄入量的最全面的全基因组关联研究(GWAS)数据(447.485),绿茶摄入量(n=64.949),调味牛奶摄入量(n=64.941),从来不吃鸡蛋,乳制品,小麦,糖:小麦产品(n=461.046),从来不吃鸡蛋,乳制品,小麦,糖:糖或含糖的食物/饮料(n=461.046),从来不吃鸡蛋,乳制品,小麦,糖:我吃所有上述(n=461.046)和特应性皮炎(n=218.467)。我们使用逆方差加权法(IVW)作为主要方法。
结果:IVW分析表明,茶摄入量增加与AD风险降低相关(比值比[OR]:0.646,95%置信区间[CI]:0.430-0.968,p=0.034)。此外,在IVW模型中,绿茶摄入量与AD显着负相关(IVWOR:0.986,95%CI:0.975-0.998;p=0.024)。从不食用小麦产品可以降低AD风险(IVWOR:8.243E-04,95%CI:7.223E-06-9.408E-02,p=0.003)。从不吃鸡蛋之间没有联系,乳制品,小麦,糖:糖,或含糖的食物/饮料,我吃了所有上述和AD。
结论:我们的MR研究表明茶摄入量之间存在因果关系,绿茶摄入量,避免食用患有特应性皮炎的小麦产品。我们的研究结果表明,预防和管理特应性皮炎可以通过从不食用小麦产品同时增加茶和绿茶的摄入量来实现。
BACKGROUND: In the continuous endeavor to find safe and efficient treatments for Atopic Dermatitis (AD), there remains a considerable focus on dietary adjustments. Nevertheless, the limited availability of research and conflicting findings in the academic literature pose a hurdle in establishing conclusive recommendations.
METHODS: Mendelian randomization (MR) was applied to the most comprehensive genome-wide association studies (GWAS) data on tea intake (447 485), green tea intake (n = 64 949), flavored milk intake (n = 64 941), never eat eggs, dairy, wheat,
sugar: Wheat products(n = 461 046), never eat eggs, dairy, wheat,
sugar:
Sugar or foods/drinks containing
sugar (n = 461 046), never eat eggs, dairy, wheat,
sugar: I eat all of the above (n = 461 046) and atopic dermatitis (n = 218 467). We used the inverse-variance weighted method (IVW) as the primary method.
RESULTS: The IVW analyses have demonstrated an increased tea intake was genetically associated with a reduced risk of AD (odds ratio [OR]: 0.646, 95% confidence interval [CI]: 0.430-0.968, p = 0.034). Furthermore, green tea intake was significantly negatively associated with AD (IVW OR: 0.986, 95% CI: 0.975-0.998; p = 0.024) in the IVW model. AD risk could be reduced by never eating wheat products (IVW OR: 8.243E-04, 95% CI: 7.223E-06-9.408E-02, p = 0.003). There was no association between never eating eggs, dairy, wheat,
sugar:
Sugar, or foods/drinks containing
sugar, I eat all of the above and AD.
CONCLUSIONS: Our MR study suggests a causal relationship between tea intake, green tea intake, and the avoidance of eating wheat products with atopic dermatitis. Our findings recommend that preventing and managing atopic dermatitis may be achieved by never eating wheat products while increasing tea and green tea intake.