背景:急性出血性水肿是一种皮肤受限的小血管白细胞碎裂性血管炎,影响4周至2岁的婴儿,并在3周内缓解。临床诊断是在未发病的儿童中进行的,这些儿童患有急性发作的环状或块状喷发和水肿。在血管炎中,type,分布,皮疹的演变从未被系统研究过。为了解决这个问题,我们采用了急性出血性水肿书目数据库中的数据,其中包括所有关于急性出血性水肿的报告。
结论:在383名儿童中记录了皮疹的主要特征。严格意义上的环形喷发,通常是类目标,在375例(98%)病例中报告(许多儿童还出现多环或arciform喷发)。数字喷发也很常见(n=358;93%)。在绝大多数病例中报告了紫癜性爆发和瘀斑。在少数病例中描述了黄斑和风团。水肿,在所有情况下都检测到,主要是痛苦的,硬结和无点蚀。以下地区受到影响,按递减顺序,由环状或nummular喷发:腿,脚,脸,武器,耳朵,树干,和生殖器。除了脚,经常受到影响,水肿的分布也相同.最初的喷发通常是一个风团或斑疹,演变成一个nummular或环形喷发。数字喷发相继演变成环形喷发。
结论:这项研究仔细地描述了类型,分布,急性出血性水肿皮肤出疹的演变。这些数据有助于医生快速,无创地对这种血管炎进行临床诊断。
BACKGROUND: Acute hemorrhagic edema is a skin-limited small-vessel leukocytoclastic vasculitis, which affects infants 4 weeks to 2 years of age and remits within 3 weeks. The diagnosis is made clinically in not-ill appearing children with acute onset of raised annular or nummular eruptions and edema. In this vasculitis, type, distribution, and evolution of the rash have never been systemically investigated. To address this issue, we employed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on acute hemorrhagic edema.
CONCLUSIONS: Key features of rash were documented in 383 children. Annular eruptions in a strict sense, usually targetoid, were reported in 375 (98%) cases (many children also presented polycyclic or arciform eruptions). Nummular eruptions were also very common (n = 358; 93%). Purpuric eruptions and ecchymoses were reported in the vast majority of cases. Macules and wheals were described in a minority of cases. Edema, detected in all cases, was mostly painful, indurated and nonpitting. The following regions were affected, in decreasing order, by annular or nummular eruptions: legs, feet, face, arms, ears, trunk, and genitals. With the exception of feet, which were very often affected, the same distribution was reported for edema. The initial eruption was often a wheal or a macule that evolved into a nummular or an annular eruption. Nummular eruptions successively evolved into annular ones.
CONCLUSIONS: This study carefully characterizes type, distribution, and evolution of skin eruption in acute hemorrhagic edema. The data help physicians to rapidly and noninvasively make the clinical diagnosis of this vasculitis.