PDF(Pubmed)
Abstract：
Dermatologic toxicities, such as urticaria and mucositis, with docetaxel, have been commonly reported; however, fixed-plaque erythrodysesthesia is a rare adverse phenomenon with a reported incidence of less than 5% of patients. Docetaxel-induced psoriasis is extremely rare, and to date, very few cases have been reported in the literature. We present a literature review of psoriasis cases secondary to docetaxel and report our own case of severe docetaxel-induced psoriasis in the setting of treatment of metastatic prostate cancer. Our patient received topical steroids and narrow-band ultraviolet B (NBUVB) light therapy with resolution of their psoriasis and was able to complete their chemotherapy without discontinuation or interruption of their docetaxel.
摘要：
皮肤毒性,如荨麻疹和粘膜炎，多西他赛，已被普遍报道；然而，固定斑块红斑感觉障碍是一种罕见的不良现象,据报道发生率低于5%的患者.多西他赛诱发的银屑病极为罕见，到目前为止，文献中报道的病例很少。我们对多西他赛继发的银屑病病例进行了文献综述，并报道了我们自己在转移性前列腺癌治疗中严重的多西他赛诱发的银屑病病例。我们的患者接受了局部类固醇和窄谱紫外线B（NBUVB）光疗，可以解决牛皮癣，并且能够完成化疗而无需停药或中断多西他赛。
