Diabetic wounds are serious clinical complications which manifest wet condition due to the mass exudate, along with disturbed regulation of inflammation, severe oxidative stress and repetitive bacterial infection. Existing treatments for diabetic wounds remain unsatisfactory due to the lack of ideal dressings that encompass mechanical performance, adherence to moist tissue surfaces, quick repair, and diverse therapeutic benefits. Herein, we fabricated a wet adhesive, self-healing, glucose-responsive drug releasing hydrogel with efficient antimicrobial and pro-healing properties for diabetic wound treatment. PAE hydrogel was constructed with poly(acrylic acid-co-acrylamide) (AA-Am) integrated with a dynamic E-F crosslinker, which consisted of epigallocatechin gallate (EGCG) and 4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic acid (AFPBA). Due to the dynamic crosslinking nature of boronate esters, abundant catechol groups and hydrogen bonding, PAE hydrogel demonstrated excellent mechanical properties with about 1000 % elongation, robust adhesion to moist tissues, fast self-healing, and absorption of biofluids of 10 times of its own weight. Importantly, PAE hydrogel exhibited sustained and glucose-responsive release of EGCG. Together, the bioactive PAE hydrogel had effective antibacterial, antioxidative, and anti-inflammatory properties in vitro, and accelerated diabetic wound healing in rats via reducing tissue-inflammatory response, enhancing angiogenesis, and reprogramming of macrophages. Overall, this versatile hydrogel provides a straightforward solution for the treatment of diabetic wound, and shows potential for other wound-related application scenarios.

Research on self-healing materials spans multiple academic disciplines and employs a variety of methodologies. Nature has been a major source of inspiration for developing self-healing materials and will likely continue to inspire innovative ideas in this field. This review article covers the principles of self-healing mechanisms, focusing on both autonomous and non-autonomous procedures. It explores both intrinsic and extrinsic self-healing abilities by considering their components, structures, and design. Additionally, a detailed analysis of the application of these materials across various sectors is provided, including aerospace, automotive, marine, energy, medical and healthcare, military, and construction. Finally, the review paper highlights the advancements in encapsulation technologies for microcapsules, their thermal stability, their mechanical properties, and the compatibility of healing agents with the matrix, which play a crucial role in the effectiveness of self-healing processes.

The commonly used ultraviolet ray (UV) curing coatings have the characteristics of fast curing speed, high hardness, strong abrasion resistance, etc. However, the self-healing properties of UV coatings after being damaged still need to be improved. Self-healing microcapsules can alleviate this problem. The UV top coating itself has good properties, so it can be directly chosen as the core material of microcapsules. UV top coating microcapsules can be added to the UV top coating to increase the self-healing properties of the UV coating to achieve the purpose of better protection of the UV coating and fiberboards. UV top coating microcapsules were prepared and added in different contents to characterize the effect on the physical, chemical, and self-healing properties of the UV coating on a fiberboard surface. The 1#, 2#, and 3# UV top coating microcapsules that were prepared with emulsifier HLB values of 10.04, 10.88, and 11.72, respectively, were added to the UV top coating at contents of 2.0%, 4.0%, 6.0%, 8.0%, and 10.0%. The UV coatings were applied to the fiberboard using a method of two primers and two top coatings, in which no microcapsule was added in the primer, and were tested and analyzed. The results showed that when the content of microcapsules was greater than 6.0%, close to 8.0%, the excessive density of microcapsules produced stacking and extrusion between the microcapsules. As a result, the core material could not flow out smoothly when part of the microcapsule was ruptured. The outflow of the core material was not efficiently utilized, thus leading to a decrease in the self-healing rate. The 2# UV top coating microcapsules of 4.0% made the UV coatings reach the self-healing rate of 26.41%. The self-healing rate of the UV coatings prepared with the 3# UV top coating microcapsules with 6.0% was up to 26.58%. The UV coatings prepared with the 1# UV top coating microcapsules of 6.0% had the highest self-healing rate among the three groups, up to 27.32%. The UV coatings of this group had the best comprehensive properties with a chromatic aberration ΔE of 4.08, a gloss of 1.10 GU, a reflectance of 17.13%, an adhesion grade of 3, a hardness of 3H, a grade 3 of impact resistance, and a roughness of 1.677 μm. An investigation of the UV coatings on fiberboard surfaces with the content of UV top coating microcapsules can provide support for the optimization of the self-healing properties of UV coatings and can also provide innovative ideas for the preparation of the self-healing coatings on fiberboard surfaces.

In this study, we report observations of propagating radial carpet beams (RCBs) through a turbulent atmosphere at ground level with a 120 m path length. RCBs are a class of nondiffracting, accelerating, self-healing, and self-amplifying beams, and generated in the diffraction of a plane wave from amplitude/phase radial gratings having different spoke numbers. Observations were made at different times of the day. The intensity profile of an RCB becomes complicated when the number of grating spokes used to generate the beam is large, and includes high intensity spots, called main intensity spots (MISs), which are symmetrically placed at the central area around the beam axis and whose number is equal to (twice) the number of spokes of the amplitude (phase) grating used to generate the beam. With the aid of a telescope and a CCD camera, successive frames of the intensity pattern of the RCBs having different levels of structural complexity are recorded at the end of the path. For the data recorded at different times of the day, we calculate the variance of displacements of MISs along the radial direction. We observe that displacements of the MISs increase with increasing mean temperature of the air; on the other hand, as the complexity of the beam intensity pattern increases, the displacements of the MISs decrease. In order to compare the resilience of different RCBs and a well-known structured beam against atmospheric turbulence, we investigate deformation of the intensity profiles of a Laguerre-Gaussian (LG) beam having a topological charge 20 and different RCBs at the end of the path. It is shown that under the same turbulence condition, highly complex RCBs are more resilient to the destructive effects of the atmospheric turbulence. In particular, for the RCBs generated with gratings having 30 spokes and more, the number of MISs of the received intensity patterns is changed by less than 1% even when the turbulence strength is high. But for the LG beam, its intensity ring is clearly broken in different places, which makes it impossible to follow its maximum intensity in the radial direction.

Onychomycosis in infants is a rare fungal infection. The condition is frequently linked to congenital or secondary immunodeficiency, as well as exposure to contaminated environments. In this report, we present a case of infant onychomycosis, likely infected during birth delivery from the mother with vaginal candidiasis. However, both the infant and the mother recovered spontaneously without any treatment over several months.

Hydrogels made from conductive organic materials have gained significant interest in recent years due to their wide range of uses, such as electrical conductors, freezing resistors, biosensors, actuators, biomedical engineering materials, drug carrier, artificial organs, flexible electronics, battery solar cells, soft robotics, and self-healers. Nevertheless, the insufficient level of effectiveness in electroconductive hydrogels serves as a driving force for researchers to intensify their endeavors in this domain. This article provides a concise overview of the recent advancements in creating self-healing single- or multi-network (double or triple) conductive hydrogels (CHs) using a range of natural and synthetic polymers and monomers. We deliberated on the efficacy, benefits, and drawbacks of several conductive hydrogels. This paper emphasizes the use of natural polymers and innovative 3D printing CHs-based technology to create self-healing conductive gels for flexible electronics. In conclusion, advantages and disadvantages have been noted, and some potential opportunities for self-healing single- or multi-network hydrogels have been proposed.

Dynamic bonds can facilitate reversible formation and dissociation of connections in response to external stimuli, endowing materials with shape memory and self-healing capabilities. Temperature is an external stimulus that can be easily controlled through heat. Dynamic covalent bonds in response to temperature can reversibly connect, exchange, and convert chains in the polymer. In this review, we introduce dynamic covalent bonds that operate without catalysts in various temperature ranges. The basic bonding mechanism and the kinetics are examined to understand dynamic covalent chemistry reversibly performed by equilibrium control. Furthermore, a recent synthesis method that implements dynamic covalent coupling based on various polymers is introduced. Dynamic covalent bonds that operate depending on temperature can be applied and expand the use of polymers, providing predictions for the development of future smart materials.

This work focused on obtaining a low-temperature powder coating characterized by self-healing properties. To achieve this, acrylic resin, blocked polyisocyanates (bPICs) with 1,2,4-triazole, and unsaturated commercial resin were used. The synthesis of bPICs with triazole enabled the low-temperature curing and reversible Diels-Alder (DA) reaction at 160 °C. The chemical structure of bPICs was confirmed using 1H-NMR. The occurrence of the DA and retro-DA (rDA) reactions in the crosslinked polymer, at temperatures of 60-85 °C and 90-130 °C, respectively, was confirmed using Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and FT-IR spectroscopy. The self-healing properties of the powder coating were examined using polarized optical microscopy. Additionally, the occurrence of the DA and rDA reactions between triazole and unsaturated polyester resin was investigated through repeated self-healing tests.

Hydrogels endure various dynamic stresses, demanding robust mechanical properties. Despite significant advancements, matching hydrogels\' strength to biological tissues and plastics is often challenging without applying potentially harmful crosslinkers. Using hydrogen bonds as sacrificial bonds offers a promising strategy to produce tough, versatile hydrogels for biomedical and industrial applications. Poly(methacrylic acid) (PMA)/gelatin hydrogels were synthesized by thermally induced free-radical polymerization and crosslinked only by physical bonds, without adding any chemical crosslinker. The addition of gelatin increased the formation of hydrophobic domains in the structure of the hydrogels, which acted as permanent crosslinking points. The increase in PMA and gelatin contents generally led to a lower equilibrium water content (WC), higher thermal stability and better mechanical properties. The values of tensile strength and toughness reached up to 1.44 ± 0.17 MPa and 4.91 ± 0.51 MJ m-3, respectively, while the compressive modulus and strength reached up to 0.75 ± 0.06 MPa and 24.81 ± 5.85 MPa, respectively, with the WC being higher than 50 wt.%. The obtained values for compressive mechanical properties are comparable with super-strong hydrogels reported in the literature. In addition, hydrogels exhibited excellent fatigue resistance and biocompatibility, as well as great shape memory properties, which make them prominent candidates for a wide range of biomedical applications.

In recent years, self-healing polymers have emerged as a topic of considerable interest owing to their capability to partially restore material properties and thereby extend the product\'s lifespan. The main purpose of this study is to investigate the nanoindentation response in terms of hardness, reduced modulus, contact depth, and coefficient of friction of a self-healing resin developed for use in aeronautical and aerospace contexts. To achieve this, the bifunctional epoxy precursor underwent tailored functionalization to improve its toughness, facilitating effective compatibilization with a rubber phase dispersed within the host epoxy resin. This approach aimed to highlight the significant impact of the quantity and distribution of rubber domains within the resin on enhancing its mechanical properties. The main results are that pure resin (EP sample) exhibits a higher hardness (about 36.7% more) and reduced modulus (about 7% more), consequently leading to a lower contact depth and coefficient of friction (11.4% less) compared to other formulations that, conversely, are well-suited for preserving damage from mechanical stresses due to their capabilities in absorbing mechanical energy. Furthermore, finite element method (FEM) simulations of the nanoindentation process were conducted. The numerical results were meticulously compared with experimental data, demonstrating good agreement. The simulation study confirms that the EP sample with higher hardness and reduced modulus shows less penetration depth under the same applied load with respect to the other analyzed samples. Values of 877 nm (close to the experimental result of 876.1 nm) and 1010 nm (close to the experimental result of 1008.8 nm) were calculated for EP and the toughened self-healing sample (EP-R-160-T), respectively. The numerical results of the hardness provide a value of 0.42 GPa and 0.32 GPa for EP and EP-R-160-T, respectively, which match the experimental data of 0.41 GPa and 0.30 GPa. This validation of the FEM model underscores its efficacy in predicting the mechanical behavior of nanocomposite materials under nanoindentation. The proposed investigation aims to contribute knowledge and optimization tips about self-healing resins.