■化脓性脊柱炎的治疗往往会延长;然而,很少有研究检查与感染控制所需时间相关的因素。因此,我们对一个连续队列患者进行分析,以确定化脓性脊柱炎感染控制所需时间的相关因素.本研究旨在阐明与化脓性脊柱炎病例实现感染控制所需持续时间相关的因素。以C反应蛋白(CRP)正常化为指标。
■在这项回顾性观察研究中,我们调查了108例诊断为化脓性脊柱炎的患者。我们评估了从第一次就诊到CRP正常化的天数;对于CRP没有正常化的病例,评估了至最终采血日期的天数.在本研究中,化脓性脊柱炎的感染控制定义为CRP在正常范围内(≤0.14mg/dL).我们进行了单变量和多变量Cox回归分析,以确定化脓性脊柱炎中与CRP正常化所需时间相关的各种因素。
■CRP正常化所需的平均时间为148天。单因素Cox回归分析显示,血清肌酐水平,估计肾小球滤过率(eGFR),淋巴细胞百分比,中性粒细胞百分比,CRP水平,CRP-白蛋白比值,中性粒细胞/淋巴细胞比率与控制感染所需的时间显著相关.多因素Cox回归分析显示,中性粒细胞百分比较高,糖尿病,eGFR较低是感染控制时间较长的独立因素。
■我们发现中性粒细胞百分比较高,糖尿病,在化脓性脊柱炎中,较低的eGFR与较长的CRP正常化时间显著相关.这些发现可能有助于识别化脓性脊柱炎患者,这些患者处于延长感染控制期的高风险中。
UNASSIGNED: Treatment for pyogenic spondylitis tends to be prolonged; however, few studies have examined the factors associated with the time required for infection control. Therefore, we analyzed a consecutive cohort of patients to identify factors associated with the time required to control infection in pyogenic spondylitis. This study aimed to clarify the factors linked to the duration necessary for achieving infection control in cases of pyogenic spondylitis, using C-reactive protein (CRP) normalization as an indicator.
UNASSIGNED: In this retrospective observational study, we investigated 108 patients diagnosed with pyogenic spondylitis. We evaluated the number of days from the first visit to CRP normalization; for cases wherein CRP did not normalize, the number of days to the date of final blood sampling was evaluated. In the present study, infection control in pyogenic spondylitis was defined as a CRP falling within the normal range (≤0.14 mg/dL). We performed univariate and multivariate Cox regression analyses to identify various factors associated with the time required for CRP normalization in pyogenic spondylitis.
UNASSIGNED: The mean time required for CRP normalization was 148 days. Univariate Cox regression analysis showed that the serum creatinine level, estimated glomerular filtration rate (eGFR), lymphocyte percentage, neutrophil percentage, CRP level, CRP-albumin ratio, and neutrophil-to-lymphocyte ratio were significantly associated with the time required to control infection. Multivariate Cox regression analysis showed that a higher neutrophil percentage, diabetes mellitus, and a lower eGFR were the independent factors associated with a longer infection control time.
UNASSIGNED: We found that a higher neutrophil percentage, diabetes mellitus, and a lower eGFR were significantly associated with a longer time for CRP normalization in pyogenic spondylitis. These findings may help identify patients with pyogenic spondylitis who are at a high risk for an extended infection control period.