PDF(Pubmed)
Abstract：
UNASSIGNED: Compared to other cancers, research on bloodstream infection in head and neck cancer is scarce, lacking comparative studies on persistent versus transient bacteremia outcomes.
UNASSIGNED: This retrospective survey examined patients with head and neck cancer undergoing blood culture at our center from June 2009 to May 2023. Blood culture-positive cases suspected of infection were divided into persistent bacteremia and transient bacteremia groups. We investigated their clinical, epidemiological, and microbiological features, including risk factors for persistent bacteremia and mortality. The primary outcome was 90-day mortality.
UNASSIGNED: In this 97-patient cohort, 14 (14%) cases were assigned to the persistent bacteremia group. Catheter-related bloodstream infections were the leading cause of infection in both groups, consistently contributing to a high proportion of overall bloodstream infections. The mortality rate was generally higher in the persistent bacteremia group than in the transient bacteremia group (odds ratio [OR], 2.6; 95% confidence interval [CI], 0.6-11.1), particularly in the non-clearance subgroup (OR, 9; 95% CI, 0.5-155.2). Pyogenic spondylitis was a key risk factor for persistent bacteremia, while hypoalbuminemia increased mortality.
UNASSIGNED: In patients with bacteremia and head and neck cancer, persistent bacteremia was associated with higher mortality than was transient bacteremia. Adittionally, bacteremia clearance in persistent bacteremia is thus crucial for prognostic improvement.
UNASSIGNED: This retrospective survey examined patients with head and neck cancer undergoing blood culture at our center from June 2009 to May 2023. Blood culture-positive cases suspected of infection were divided into persistent bacteremia and transient bacteremia groups. We investigated their clinical, epidemiological, and microbiological features, including risk factors for persistent bacteremia and mortality. The primary outcome was 90-day mortality.
UNASSIGNED: In this 97-patient cohort, 14 (14%) cases were assigned to the persistent bacteremia group. Catheter-related bloodstream infections were the leading cause of infection in both groups, consistently contributing to a high proportion of overall bloodstream infections. The mortality rate was generally higher in the persistent bacteremia group than in the transient bacteremia group (odds ratio [OR], 2.6; 95% confidence interval [CI], 0.6-11.1), particularly in the non-clearance subgroup (OR, 9; 95% CI, 0.5-155.2). Pyogenic spondylitis was a key risk factor for persistent bacteremia, while hypoalbuminemia increased mortality.
UNASSIGNED: In patients with bacteremia and head and neck cancer, persistent bacteremia was associated with higher mortality than was transient bacteremia. Adittionally, bacteremia clearance in persistent bacteremia is thus crucial for prognostic improvement.
摘要：
■与其他癌症相比，对头颈癌血流感染的研究很少，缺乏持续性和一过性菌血症结局的比较研究。
■这项回顾性调查检查了2009年6月至2023年5月在我们中心接受血液培养的头颈部癌症患者。将怀疑感染的血培养阳性病例分为持续性菌血症组和一过性菌血症组。我们调查了他们的临床，流行病学,和微生物学特征，包括持续性菌血症和死亡率的危险因素。主要结果是90天死亡率。
■在这个97名患者队列中，14例（14％）被分配到持续菌血症组。导管相关性血流感染是两组感染的主要原因,持续导致高比例的整体血液感染。持续菌血症组的死亡率普遍高于一过性菌血症组（比值比[OR]，2.6；95%置信区间[CI]，0.6-11.1),特别是在非清除亚组(OR，9；95%CI，0.5-155.2）。化脓性脊柱炎是持续菌血症的关键危险因素，而低白蛋白血症增加死亡率。
■在菌血症和头颈癌患者中，持续性菌血症的死亡率高于一过性菌血症.Aditally,因此,清除持续性菌血症对改善预后至关重要.
■这项回顾性调查检查了2009年6月至2023年5月在我们中心接受血液培养的头颈部癌症患者。将怀疑感染的血培养阳性病例分为持续性菌血症组和一过性菌血症组。我们调查了他们的临床，流行病学,和微生物学特征，包括持续性菌血症和死亡率的危险因素。主要结果是90天死亡率。
■在这个97名患者队列中，14例（14％）被分配到持续菌血症组。导管相关性血流感染是两组感染的主要原因,持续导致高比例的整体血液感染。持续菌血症组的死亡率普遍高于一过性菌血症组（比值比[OR]，2.6；95%置信区间[CI]，0.6-11.1),特别是在非清除亚组(OR，9；95%CI，0.5-155.2）。化脓性脊柱炎是持续菌血症的关键危险因素，而低白蛋白血症增加死亡率。
■在菌血症和头颈癌患者中，持续性菌血症的死亡率高于一过性菌血症.Aditally,因此,清除持续性菌血症对改善预后至关重要.
