polyclonal cells

多克隆细胞
  • 文章类型: Case Reports
    缩窄性心包炎(CP)表现为一种病理生理状态,其中心包由于纤维化变化而变得无弹性。最常见的是继发于持续的炎症过程。该疾病的特征在于由于心包顺应性的丧失而导致的舒张心功能受损。免疫球蛋白G4(IgG4)相关疾病,以IgG4阳性浆细胞的隐伏增殖和随后的各种器官内的纤维化为标志的实体,是CP的罕见但公认的原因。一名55岁的男性患者的下肢呼吸困难和水肿的临床表现阐明了CP固有的诊断复杂性。超声心动图显示一系列迹象,包括环回复,间隔弹跳,和充血下腔静脉;心脏磁共振成像(MRI)显示弥漫性心包增厚伴钆增强延迟,提示长期炎症状态;右心导管检查证实了心脏腔舒张压CP均衡的血流动力学标志。血清学分析显示血清IgG4和IgE水平升高,指出IgG4相关疾病的鉴别诊断。鉴于IgG4相关CP的非特异性临床表现,增强的怀疑指数与系统的影像学和血清学评估方法相结合是最重要的。
    Constrictive pericarditis (CP) presents as a pathophysiological state where the pericardium becomes inelastic due to fibrotic changes, most commonly secondary to a protracted inflammatory process. The disease is characterized by compromised diastolic cardiac function due to loss of pericardial compliance. Immunoglobulin G4 (IgG4)-related disease, an entity marked by the insidious proliferation of IgG4-positive plasma cells and subsequent fibrosis within various organs, is an infrequent but recognized cause of CP. A case of a 55-year-old male patient with clinical manifestations of dyspnea and edema in the lower extremities elucidates the diagnostic complexity inherent to CP. Echocardiography revealed a constellation of signs, including annulus reversus, septal bounce, and a congested inferior vena cava; cardiac magnetic resonance imaging (MRI) demonstrated diffuse pericardial thickening with delayed gadolinium enhancement, suggestive of a long-term inflammatory state; and right heart catheterization confirmed the hemodynamic hallmark of CP-equalization of diastolic pressures across the cardiac chambers. The serological analysis elicited elevated serum levels of IgG4 and IgE, pointing to the differential diagnosis of IgG4-related disease. Given the nonspecific clinical presentation of IgG4-related CP, a heightened index of suspicion combined with a systematic approach to imaging and serological evaluation is paramount.
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  • 文章类型: Case Reports
    卵泡淋巴样增生是一种罕见的口腔粘膜反应性良性病变。这也被称为假性淋巴瘤,其特征是模仿恶性对应物滤泡性淋巴瘤。在目前的情况下,一名34岁的男性患者在舌头的后外侧左侧出现结节状肿胀。病史或牙齿病史无贡献。肿胀是无痛的,很好的划界,大约花生大小。肿胀暂时被诊断为神经鞘瘤,粘液囊肿,或者是创伤性纤维瘤.进行了完全切除,组织被送到私人实验室.观察到的组织病理学发现是生发中心,其核心是相同大小的单调细胞,并划定了模仿淋巴瘤的地幔区域。免疫表型分析显示κ和λ表达呈扩散阳性。CD10在生发中心呈弥漫性阳性,BCl2在地幔区呈阳性,而在生发中心呈阴性。最终诊断为滤泡性淋巴样增生。本文提到的实体是良性淋巴增生性病变的不寻常变体,在舌区报道的病例很少。因此,重要的是要从各个方面了解这种良性病变的性质,以避免由于其恶性镜像特征而导致的诊断困境。
    Follicular lymphoid hyperplasia is a rare reactive benign lesion of the oral mucosa. This is also known as pseudolymphoma as the features mimic the malignant counterpart Follicular lymphoma. In present case, a 34 year old male patient came with a nodular swelling in the posterior-lateral left side of tongue. Medical or dental history was non contributory. Swelling was painless, well demarcated, and about peanut sized. The swelling was provisionally diagnosed as either neurilemmoma, mucocele, or traumatic fibroma. Complete excision was performed, and tissue was sent to a private laboratory. Histopathological findings seen were germinal centers having a core of monotonous cells of the same size and demarcated mantle area mimicking the lymphoma. Immunophenotyping revealed diffused positivity for kappa and lambda expressions. CD10 was diffusely positive in germinal centers and BCl 2 was positive in the mantle area while negative in germinal centers. The final diagnosis given was follicular lymphoid hyperplasia. The entity mentioned in the present paper is an unusual variant of the benign lymphoproliferative lesion and very few cases are reported in the tongue area. Thus, it is important to understand the nature of this benign lesion in all aspects to avoid diagnostic dilemmas due to its malignant mirroring characteristics.
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