PDF(Pubmed)
Abstract：
Follicular lymphoid hyperplasia is a rare reactive benign lesion of the oral mucosa. This is also known as pseudolymphoma as the features mimic the malignant counterpart Follicular lymphoma. In present case, a 34 year old male patient came with a nodular swelling in the posterior-lateral left side of tongue. Medical or dental history was non contributory. Swelling was painless, well demarcated, and about peanut sized. The swelling was provisionally diagnosed as either neurilemmoma, mucocele, or traumatic fibroma. Complete excision was performed, and tissue was sent to a private laboratory. Histopathological findings seen were germinal centers having a core of monotonous cells of the same size and demarcated mantle area mimicking the lymphoma. Immunophenotyping revealed diffused positivity for kappa and lambda expressions. CD10 was diffusely positive in germinal centers and BCl 2 was positive in the mantle area while negative in germinal centers. The final diagnosis given was follicular lymphoid hyperplasia. The entity mentioned in the present paper is an unusual variant of the benign lymphoproliferative lesion and very few cases are reported in the tongue area. Thus, it is important to understand the nature of this benign lesion in all aspects to avoid diagnostic dilemmas due to its malignant mirroring characteristics.
摘要：
卵泡淋巴样增生是一种罕见的口腔粘膜反应性良性病变。这也被称为假性淋巴瘤，其特征是模仿恶性对应物滤泡性淋巴瘤。在目前的情况下，一名34岁的男性患者在舌头的后外侧左侧出现结节状肿胀。病史或牙齿病史无贡献。肿胀是无痛的,很好的划界，大约花生大小。肿胀暂时被诊断为神经鞘瘤，粘液囊肿,或者是创伤性纤维瘤.进行了完全切除，组织被送到私人实验室.观察到的组织病理学发现是生发中心，其核心是相同大小的单调细胞，并划定了模仿淋巴瘤的地幔区域。免疫表型分析显示κ和λ表达呈扩散阳性。CD10在生发中心呈弥漫性阳性，BCl2在地幔区呈阳性，而在生发中心呈阴性。最终诊断为滤泡性淋巴样增生。本文提到的实体是良性淋巴增生性病变的不寻常变体，在舌区报道的病例很少。因此，重要的是要从各个方面了解这种良性病变的性质，以避免由于其恶性镜像特征而导致的诊断困境。
