■由于胰腺导管腺癌(PDAC)的诊断和治疗薄弱,早期检测PDAC可能的生物标志物是本研究的主要目的。
■PDAC被称为外分泌癌,5年总生存率为11%。
■从基因表达综合(GEO)下载PDAC组织和正常组织早期的基因表达谱,并通过GEO2R评估。通过蛋白质-蛋白质相互作用(PPI)网络分析和基因本体论研究了显着的差异表达基因(DEGs)。
■在104度中,ALB,COL1A1,COL1A2,MMP1,POSTN,部队,和COL3A1被指出为集线器节点。“明胶降解MMP1、2、3、7、8、9、12、13”组52个生物学术语被确定为主要受影响的术语。
■总而言之,ALB,MMP1和COL1A1基因被强调为PDAC早期的可能生物标志物。细胞外基质功能障碍被确定为患者的主要事件。
UNASSIGNED: Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.
UNASSIGNED: PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.
UNASSIGNED: Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology.
UNASSIGNED: Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. \"Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13\" group of 52 biological terms were identified as the main affected terms.
UNASSIGNED: In conclusion, ALB, MMP1, and COL1A1 genes were highlighted as possible biomarkers of early stage of PDAC. Dysfunction of extracellular matrix was identified as a main event in patients.