PDF(Pubmed)
Abstract：
Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term \"ncRNA\" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are growing. In this review, it is aimed to provide critical information about lncRNAs in PC, including the biological and oncological behaviors of lncRNAs in PC and their potential application in therapeutic strategies and as diagnostic tumor markers.
摘要：
长链非编码RNA(lncRNA)是具有由200个或更多个核苷酸组成的异质结构的非编码RNA分子。因为这些非编码RNA是由RNA聚合酶II转录的，它们具有类似于信使RNA(mRNA)的特性。与普遍的看法相反，术语“ncRNA”起源于发现microRNA之前。LncRNA基因比蛋白质编码基因更多。它们是当前分子研究的焦点，因为它们在癌症相关过程中的关键作用，如细胞增殖，分化,和移民。胰腺癌（PC）的发病率在世界范围内不断增加，对PC分子方面的研究也在不断增长。在这次审查中,它旨在提供有关PC中的lncRNAs的关键信息，包括PC中lncRNAs的生物学和肿瘤行为及其在治疗策略和诊断肿瘤标志物中的潜在应用。
