用于生物医学目的的酵母越来越频繁地用于递送预防和治疗产品。它的结构部件,如β-葡聚糖,甘露聚糖,还有甲壳素,可以作为免疫刺激剂进行探索,显示出安全性和低毒性。此外,该系统最大限度地减少给药后的抗原降解,促进向靶细胞的递送。
■这篇综述试图介绍来自酵母的分子,称为酵母壳(YS),以及它们作为药物载体的应用,蛋白质,和用于免疫治疗目的的核酸。此外,由于有关这些化合物的生产和免疫刺激的信息的多样性,我们对方案和免疫应答谱进行了调查.
■YS的使用已允许开发出在抗原递送中结合效率和有效性的策略。所述荚膜结构可被树突状细胞和巨噬细胞识别和吞噬。此外,与不同分子的组合,如纳米颗粒或甚至额外的佐剂,提高了货物的装载,增强系统。通过特异性免疫途径的活化也可以通过不同的施用途径来实现。
■以不同方式组合的酵母衍生物可以增加免疫刺激,增强药物和疫苗抗原的递送。这些方面,结合生产步骤的简单性,使这些策略更易于应用于各种疾病的预防和治疗。
UNASSIGNED: The employment of yeasts for biomedical purposes has become increasingly frequent for the delivery of prophylactic and therapeutic products. Its structural components, such as β-glucans, mannan, and chitin, can be explored as immunostimulators that show safety and low toxicity. Besides, this system minimizes antigen degradation after administration, facilitating the delivery to the target cells.
UNASSIGNED: This review sought to present molecules derived from yeast, called yeast shells (YS), and their applications as carrier vehicles for drugs, proteins, and nucleic acids for immunotherapy purposes. Furthermore, due to the diversity of information regarding the production and immunostimulation of these compounds, a survey of the protocols and immune response profiles generated was presented.
UNASSIGNED: The use of YS has allowed the development of strategies that combine efficiency and effectiveness in antigen delivery. The capsular structure can be recognized and phagocytized by dendritic cells and macrophages. In addition, the combination with different molecules, such as nanoparticles or even additional adjuvants, improves the cargo loading, enhancing the system. Activation by specific immune pathways can also be achieved by different administration routes.
UNASSIGNED: Yeast derivatives combined in different ways can increase immunostimulation, enhancing the delivery of medicines and vaccine antigens. These aspects, combined with the simplicity of the production steps, make these strategies more accessible to be applied in the prevention and treatment of various diseases.