背景:先天性失语症(CA)是一种罕见的疾病,其特征是音高感知缺陷,并且已经进行了许多结构和功能磁共振成像研究,以更好地了解其神经基础。然而,尚未进行使用基于表面的形态学方法的结构磁共振成像分析,以在基于顶点的水平上识别具有皮质特征异常的区域。方法:15名CA患者和13名健康对照者接受了结构磁共振成像。使用基于表面的形态学方法来识别解剖异常。然后,提取并比较了具有统计学意义的组间差异的已识别簇的表面参数平均值。最后,Pearson的相关性分析用于评估蒙特利尔Amusia评估电池(MBEA)评分与表面参数之间的相关性。结果:CA组的MBEA评分明显低于健康对照组(p=0.000)。与健康对照组相比,CA组的右尾中额回显着更高的分形维数,右三角回的沟深度更低(p<0.05;在簇水平上校正的错误发现率)。右尾中额回平均分形维数与MBEA评分呈负相关,包括平均MBEA评分(r=-0.5398,p=0.0030),量表评分(r=-0.5712,p=0.0015),等高线得分(r=-0.4662,p=0.0124),间隔得分(r=-0.4564,p=0.0146),节奏评分(r=-0.5133,p=0.0052),计分(r=-0.3937,p=0.0382),和记忆得分(r=-0.3879,p=0.0414)。右侧三角回平均沟深度与MBEA评分呈显著正相关,包括平均得分(r=0.5130,p=0.0052),量表评分(r=0.5328,p=0.0035),间隔得分(r=0.4059,p=0.0321),节奏评分(r=0.5733,p=0.0014),计分(r=0.5061,p=0.0060),和记忆得分(r=0.4001,p=0.0349)。结论:CA患者右半球出现皮质形态学改变。这些发现可能表明,CA患者言语感知和记忆障碍的神经基础与右三角回和中额回的异常有关。这些皮质异常可能是CA的神经标记。
Background: Congenital amusia (CA) is a rare disorder characterized by deficits in pitch perception, and many structural and functional magnetic resonance imaging studies have been conducted to better understand its neural bases. However, a structural magnetic resonance imaging analysis using a surface-based morphology method to identify regions with cortical features abnormalities at the vertex-based level has not yet been performed. Methods: Fifteen participants with CA and 13 healthy controls underwent structural magnetic resonance imaging. A surface-based morphology method was used to identify anatomical abnormalities. Then, the surface parameters\' mean value of the identified clusters with statistically significant between-group differences were extracted and compared. Finally, Pearson\'s correlation analysis was used to assess the correlation between the Montreal Battery of Evaluation of Amusia (MBEA) scores and surface parameters. Results: The CA group had significantly lower MBEA scores than the healthy controls (p = 0.000). The CA group exhibited a significant higher fractal dimension in the right caudal middle frontal gyrus and a lower sulcal depth in the right pars triangularis gyrus (p < 0.05; false discovery rate-corrected at the cluster level) compared to healthy controls. There were negative correlations between the mean fractal dimension values in the right caudal middle frontal gyrus and MBEA score, including the mean MBEA score (r = -0.5398, p = 0.0030), scale score (r = -0.5712, p = 0.0015), contour score (r = -0.4662, p = 0.0124), interval score (r = -0.4564, p = 0.0146), rhythmic score (r = -0.5133, p = 0.0052), meter score (r = -0.3937, p = 0.0382), and memory score (r = -0.3879, p = 0.0414). There was a significant positive correlation between the mean sulcal depth in the right pars triangularis gyrus and the MBEA score, including the mean score (r = 0.5130, p = 0.0052), scale score (r = 0.5328, p = 0.0035), interval score (r = 0.4059, p = 0.0321), rhythmic score (r = 0.5733, p = 0.0014), meter score (r = 0.5061, p = 0.0060), and memory score (r = 0.4001, p = 0.0349). Conclusion: Individuals with CA exhibit cortical morphological changes in the right hemisphere. These findings may indicate that the neural basis of speech perception and memory impairments in individuals with CA is associated with abnormalities in the right pars triangularis gyrus and middle frontal gyrus, and that these cortical abnormalities may be a neural marker of CA.