分析喉癌患者全喉切除术后咽皮瘘(PCF)的危险因素及愈合因素。并探讨相关的流行病学。回顾性分析2010年1月至2022年12月在我院行全喉切除术的喉癌患者的临床资料。纳入研究的349例患者分为PCF组79例和非PCF组270例。对纳入统计量的患者的各种数据进行单因素方差分析和多因素logistic分析,并分析PCF的危险因素和治愈因素。吸烟,喉癌放射治疗史,喉癌化疗史,肿瘤位置(喉,咽部,食管),术前白蛋白,术后蛋白血症,<99血红蛋白,术后血红蛋白,术后C反应蛋白(CRP)水平是PCF的危险因素。此外,放射治疗和术后蛋白血症是阻止PCF愈合的主要原因。吸烟史,喉癌,放射治疗,白蛋白,血红蛋白和CRP是全喉切除术后PCF的危险因素,而放射治疗和术后低白蛋白血症是影响PCF愈合的关键因素。
To analyse the risk factors and healing factors of pharyngocutaneous fistula (PCF) in patients with laryngeal cancer after total
laryngectomy, and to explore the relevant epidemiology. A retrospective analysis was conducted on laryngeal cancer patients who underwent total
laryngectomy in our hospital from January 2010 to December 2022. The 349 patients included in the study were divided into a PCF group of 79 and a non-PCF group of 270. Perform one-way analysis of variance and multivariate logistic analysis on various data of patients included in the statistics, and analyse the risk factors and healing factors of PCF. Smoking, history of radiation therapy for laryngeal cancer, history of chemotherapy for laryngeal cancer, tumour location (larynx, pharynx, oesophagus), preoperative albumin, postoperative proteinaemia, <99 haemoglobin, postoperative haemoglobin, postoperative C-reactive protein (CRP) level are the risk factors for PCF. Also, radiation therapy and postoperative proteinaemia were the main reasons for preventing PCF healing. Smoking history, laryngeal cancer, radiation therapy, albumin, haemoglobin and CRP are risk factors for postoperative PCF after total
laryngectomy, while radiation therapy and postoperative hypoalbuminaemia are key factors affecting PCF healing.